Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
Division of Risk Assessment, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
Viruses. 2021 Oct 17;13(10):2089. doi: 10.3390/v13102089.
This study investigated the infectivity of severe acute respiratory syndrome (SARS-CoV-2) in individuals who re-tested positive for SARS-CoV-2 RNA after recovering from their primary illness. We investigated 295 individuals with re-positive SARS-CoV-2 polymerase chain reaction (PCR) test results and 836 of their close contacts. We attempted virus isolation in individuals with re-positive SARS-CoV-2 PCR test results using cell culture and confirmed the presence of neutralizing antibodies using serological tests. Viral culture was negative in all 108 individuals with re-positive SARS-CoV-2 PCR test results in whom viral culture was performed. Three new cases of SARS-CoV-2 infection were identified among household contacts using PCR. Two of the three new cases had had contact with the index patient during their primary illness, and all three had antibody evidence of past infection. Thus, there was no laboratory evidence of viral shedding and no epidemiological evidence of transmission among individuals with re-positive SARS-CoV-2 PCR test results.
这项研究调查了在从原发性疾病中康复后重新检测到 SARS-CoV-2 RNA 阳性的个体中，SARS-CoV-2 的传染性。我们调查了 295 名重新检测到 SARS-CoV-2 聚合酶链反应（PCR）测试结果阳性的个体及其 836 名密切接触者。我们尝试使用细胞培养对重新检测到 SARS-CoV-2 PCR 测试结果阳性的个体进行病毒分离，并使用血清学测试确认中和抗体的存在。在所有重新检测到 SARS-CoV-2 PCR 测试结果阳性的 108 名个体中，病毒培养均为阴性。通过 PCR 在家庭接触者中发现了 3 例新的 SARS-CoV-2 感染病例。这 3 例新病例中有 2 例在原发性疾病期间与指数患者接触，所有 3 例均有过去感染的抗体证据。因此，在重新检测到 SARS-CoV-2 PCR 测试结果阳性的个体中，没有实验室证据表明病毒脱落，也没有流行病学证据表明传播。
