关于血红蛋白的扩展X射线吸收精细结构研究。
On extended x-ray absorption fine structure studies of hemoglobin.
作者信息
Shulman R G
出版信息
Proc Natl Acad Sci U S A. 1987 Feb;84(4):973-4. doi: 10.1073/pnas.84.4.973.
Results of extended x-ray absorption fine structure (EXAFS) studies of the iron atom in deoxygenated hemoglobin are reviewed. It is shown that the iron-porphinato nitrogen distance has been determined to be 2.06 +/- 0.01 A by two independent investigations [Eisenberger, P.M., Shulman, R.G., Kincaid, B. M., Brown, G. S. & Ogawa, S. (1978) Nature (London) 274, 30-34 and Perutz, M.F., Hasnain, S.S., Duke, P.J., Sessler, J.L. & Hahn, J.E. (1982) Nature (London) 295, 535-538]. Difficulties experienced by Perutz et al. in using this distance to calculate the iron's distance above the plane by triangulation are shown to be due to ignoring differences between ferrous and ferric hemes. It is concluded that the iron is 0.2 +/- 0.1 0.2 A above the plane of the nitrogens as originally shown by Eisenberger et al.
本文综述了对脱氧血红蛋白中铁原子进行扩展X射线吸收精细结构（EXAFS）研究的结果。两项独立研究[艾森伯格，P.M.，舒尔曼，R.G.，金凯德，B.M.，布朗，G.S.和小川，S.（1978年）《自然》（伦敦）274，30 - 34；佩鲁茨，M.F.，哈斯奈因，S.S.，杜克，P.J.，塞斯勒，J.L.和哈恩，J.E.（1982年）《自然》（伦敦）295，535 - 538]表明，铁-卟啉氮距离已确定为2.06±0.01埃。结果表明，佩鲁茨等人在通过三角测量法利用该距离计算铁原子在平面上方的距离时遇到的困难，是由于忽略了亚铁血红素和高铁血红素之间的差异。结论是，如艾森伯格等人最初所示，铁原子在氮平面上方0.2±0.1埃。
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