带状疱疹疫苗可降低患痴呆症的风险。
Herpes Zoster Vaccination Reduces Risk of Dementia.
作者信息
Lehrer Steven, Rheinstein Peter H
机构信息
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.;
Severn Health Solutions, Severna Park, MD, U.S.A.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3271-3275. doi: 10.21873/invivo.12622.
UNLABELLED
Background/Αim: The relationship of herpes viruses and herpes zoster (HZ) with dementia and Alzheimer's disease is controversial. This study evaluated the relationship between HZ vaccination and cognitive impairment.
PATIENTS AND METHODS
We used data from The Behavioral Risk Factor Surveillance System (BRFSS) to evaluate the relationship between HZ vaccination and cognitive impairment.
RESULTS
Using BRFSS 2017 data, we assessed HZ vaccination status in 275 subjects whose social activities were hampered by disorientation or memory loss. 61.6% of vaccinated subjects (n=61) and 46.6% of unvaccinated subjects (n=82) never had social activities hampered by disorientation or memory loss. The result is significant (p=0.025, two- sided Fisher exact test). The results of multivariate linear regression analysis, considering social activities hampered by disorientation or memory loss as a dependent variable, and vaccination (yes or no), sex, and education level as independent variables, showed that the effect of vaccination--reducing risk of social activities hampered by disorientation or memory loss--was significant (p=0.03).
CONCLUSION
Our finding that HZ vaccination reduces the risk of dementia is consistent with the link between viruses and AD. Herpes viruses-induced reactivation of embryologic pathways silenced at birth could be one of the pathologic processes in Alzheimer's disease.
未标注
背景/目的：疱疹病毒及带状疱疹（HZ）与痴呆和阿尔茨海默病之间的关系存在争议。本研究评估了HZ疫苗接种与认知障碍之间的关系。
患者与方法
我们使用行为危险因素监测系统（BRFSS）的数据来评估HZ疫苗接种与认知障碍之间的关系。
结果
利用2017年BRFSS数据，我们评估了275名社交活动因定向障碍或记忆丧失而受阻的受试者的HZ疫苗接种状况。接种疫苗的受试者中有61.6%（n = 61）、未接种疫苗的受试者中有46.6%（n = 82）的社交活动从未因定向障碍或记忆丧失而受阻。结果具有显著性（p = 0.025，双侧Fisher精确检验）。多变量线性回归分析结果显示，以因定向障碍或记忆丧失而受阻的社交活动作为因变量，以疫苗接种（是或否）、性别和教育水平作为自变量，疫苗接种降低因定向障碍或记忆丧失而受阻的社交活动风险的作用具有显著性（p = 0.03）。
结论
我们关于HZ疫苗接种可降低痴呆风险的发现与病毒和阿尔茨海默病之间的联系一致。疱疹病毒诱导出生时沉默的胚胎学途径重新激活可能是阿尔茨海默病的病理过程之一。
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