前列腺癌适形分割放疗中应用水凝胶 spacer 注射间隙保护器官的临床结果
Clinical Outcomes of Hydrogel Spacer Injection Space OAR in Men Submitted to Hypofractionated Radiotherapy for Prostate Cancer.
机构信息
Urology Unit, Cannizzaro Hospital, Catania, Italy
Radiotherapy Unit, Cannizzaro Hospital, Catania, Italy.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3385-3389. doi: 10.21873/invivo.12637.
Abstract
BACKGROUND/AIM: To evaluate the clinical outcomes of men with prostate cancer (PCa) submitted to hydrogel spacer injection before hypofractionated radiotherapy (HRT).
PATIENTS AND METHODS
From April 2018 to April 2020, 32 patients with clinically localized PCa underwent hydrogel injection Space OAR before HRT to the prostate and seminal vesicle; the prescription dose was 60 Gy in 20 fractions, 5 days/week over 4 weeks. PSA levels, genitourinary (GU) and gastrointestinal (GI) toxicities, and sexual function were prospectively evaluated.
RESULTS
PSA levels at the median follow up of 15 months was 0.52 ng/ml; 28.1% vs. 78.1% patients had GI vs. GU Grade 0 acute toxicity and 93.7% vs. 0% had GI vs. GU Grade 0 late toxicity. Furthermore, 88.1% of patients kept pretreatment sexual potency.
CONCLUSION
The use of the hydrogel Spacer OAR before HRT is useful for reducing acute and late GU and GI toxicities.
摘要
背景/目的：评估前列腺癌（PCa）患者在接受低分割放疗（HRT）前接受水凝胶间隔物注射的临床结果。
患者和方法
从 2018 年 4 月至 2020 年 4 月，32 例临床局限性 PCa 患者在 HRT 对前列腺和精囊前接受水凝胶注射间隔物 Space OAR；处方剂量为 60Gy，20 次分割，每周 5 天，共 4 周。前瞻性评估 PSA 水平、泌尿生殖系统（GU）和胃肠道（GI）毒性以及性功能。
结果
中位随访 15 个月时 PSA 水平为 0.52ng/ml；28.1%和 78.1%的患者分别出现 GI 级和 GU 级急性毒性 0 级，93.7%和 0%的患者分别出现 GI 级和 GU 级晚期毒性 0 级。此外，88.1%的患者保持了治疗前的性能力。
结论
在 HRT 前使用水凝胶 Spacer OAR 有助于降低急性和晚期 GU 和 GI 毒性。
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