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“肮脏的猪”与异种移植悖论。

'Dirty pigs' and the xenotransplantation paradox.

机构信息

Science Technology and Innovation Studies, University of Edinburgh, Edinburgh, UK

出版信息

Med Humanit. 2021 Dec;47(4):417-424. doi: 10.1136/medhum-2021-012187. Epub 2021 Oct 25.

Abstract

For almost the last 300 years human beings have sought to use organs from non-human animals to repair or replace their own failing organs. This procedure of intraspecies transplant is called xenotransplantation, and despite the continued attempts by researchers, it is yet to be successful. Experiments in xenotransplantation persist, however, partly based on the perceived biological similarities that exist between humans and non-human animals despite the success of xenotransplantation being hampered by the ability of the human body's immune system to attack and therefore reject foreign material. In this article, I explore the sociocultural reactions to xenotransplantation which demonstrates that it is based on a paradox; although non-human animals and humans are thought to be biologically compatible or , many assume and emphasise just how we are from non-human animals. These two positions of 'same but different' are arguably incompatible. I begin by reviewing social science research that demonstrates, despite some variation, a range of persistent concerns towards xenotransplantation including the consequences for personal identity should a person receive a non-human animal organ. I add to this body of work, findings from a mixed-method study involving focus groups and a representative survey with young adults to show that most people prefer to have their organs replaced by materials from their own body and non-human animals the least. These reactions sit within a broader context of a 'wisdom of repugnance' that is brought into existence when our classifications of what is thought to be natural or not is threatened.

摘要

近 300 年来,人类一直试图使用非人类动物的器官来修复或替代自己衰竭的器官。这种同种异体移植的过程被称为异种移植,尽管研究人员不断尝试,但它尚未成功。异种移植实验仍在继续,部分原因是基于人类和非人类动物之间存在的生物相似性,尽管异种移植的成功受到人体免疫系统攻击和因此排斥异物的能力的阻碍。在本文中,我探讨了对异种移植的社会文化反应,这表明它基于一个悖论;尽管非人类动物和人类在生物学上被认为是相容的,或者说,许多人认为我们与非人类动物有很大的不同。这两种“相同但不同”的立场可以说是不相容的。我首先回顾了社会科学研究,这些研究表明,尽管存在一些差异,但人们对异种移植存在一系列持续的担忧,包括如果一个人接受非人类动物器官,个人身份会发生什么后果。我在这一研究领域的基础上,增加了一项涉及焦点小组和代表性调查的混合方法研究的结果,表明大多数人更喜欢用自己身体和非人类动物的材料来替换自己的器官,而不是非人类动物的器官。这些反应存在于一种更广泛的“反感智慧”背景下,当我们对自然或非自然的分类受到威胁时,这种智慧就会出现。

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本文引用的文献

1
Xenotransplantation: Current Status in Preclinical Research.异种移植:临床前研究的现状。
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3
Troubling dimensions of heart transplantation.心脏移植令人担忧的方面。
Med Humanit. 2009 Jun;35(1):35-8. doi: 10.1136/jmh.2008.001073.
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Proc (Bayl Univ Med Cent). 2012 Jan;25(1):49-57. doi: 10.1080/08998280.2012.11928783.
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Our social genome?
Trends Biotechnol. 2007 Jul;25(7):284-8. doi: 10.1016/j.tibtech.2007.04.006. Epub 2007 Apr 30.
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The xenotransplantation narratives of nine type 1 diabetic patients with renal failure.
Xenotransplantation. 2006 Nov;13(6):509-11. doi: 10.1111/j.1399-3089.2006.00352_4.x.

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