Research Team in Neurology and Neurogenetics, Genomic Center of Human Pathologies, Medical School and Pharmacy, University Mohammed V in Rabat, Impasse Souissi, 10100 Rabat, Morocco.
Research Team in Neurology and Neurogenetics, Genomic Center of Human Pathologies, Medical School and Pharmacy, University Mohammed V in Rabat, Impasse Souissi, 10100 Rabat, Morocco; Rabat-Instituts, Department of Neurology and Neurogenetics, Specialties Hospital, ONO, University Hospital of Rabat-Salé, BP 6444, Rabat, Morocco.
Rev Neurol (Paris). 2018 Mar;174(3):150-156. doi: 10.1016/j.neurol.2017.06.030. Epub 2018 Mar 7.
Growing evidence suggests that hypovitaminosis D contributes to the pathogenesis of multiple sclerosis (MS).
This study aimed to evaluate whether vitamin D levels are associated with having MS and some of its characteristics in the Moroccan population.
Using liquid chromatography-tandem mass spectrometry, the 25(OH)D metabolite was measured to quantify vitamin D serum levels (DSLs) in 113 patients with MS and 146 healthy controls matched for gender and age. DSLs were then compared between patients and controls, with correlations sought between DSLs and gender, age at onset, disease duration, MS type, degree of disability (EDSS score) and disease severity (MSSS) in patients.
Hypovitaminosis D (DSL<30ng/mL) was observed in 97.3% of MS patients and in 98.6% of controls. Although the mean DSL was slightly lower in patients (11.69±6.97ng/mL) than in controls (12.98±6.58ng/mL), there was no significant association between DSL and MS status (P=0.131). Similarly, among patients, no apparent association was found between DSL and MS type (P=0.214), EDSS score (P=0.076) or MSSS (P=0.772).
Our study suggests that DSL is not associated with having MS nor with MS type, degree of disability or disease severity in the Moroccan population. On the other hand, DSL was lower in women and decreased with age.
越来越多的证据表明，维生素 D 缺乏症与多发性硬化症（MS）的发病机制有关。
本研究旨在评估摩洛哥人群的维生素 D 水平是否与多发性硬化症及其某些特征有关。
采用液相色谱-串联质谱法，测量 25（OH）D 代谢物以定量血清维生素 D 水平（DSL），共纳入 113 例 MS 患者和 146 例性别和年龄匹配的健康对照者。比较患者和对照组之间的 DSL，寻求 DSL 与性别、发病年龄、疾病持续时间、MS 类型、残疾程度（EDSS 评分）和疾病严重程度（MSSS）之间的相关性。
97.3%的 MS 患者和 98.6%的对照组存在维生素 D 缺乏症（DSL<30ng/ml）。尽管患者的平均 DSL 略低于对照组（11.69±6.97ng/ml vs. 12.98±6.58ng/ml），但 DSL 与 MS 状态之间无显著相关性（P=0.131）。同样，在患者中，DSL 与 MS 类型（P=0.214）、EDSS 评分（P=0.076）或 MSSS（P=0.772）之间也无明显相关性。
本研究表明，在摩洛哥人群中，DSL 与 MS 无关，也与 MS 类型、残疾程度或疾病严重程度无关。另一方面，DSL 在女性中较低，且随年龄增长而降低。
