Csizmadia Sándor, Fodor Gergely H, Palkó András, Vörös Erika
Affidea Hungary Ltd. Budapest, 44-46 Bókay János Street, Budapest H-1083, Hungary.
Department of Medical Physics and Informatics, University of Szeged, Faculty of General Medicine, 9 Korányi Alley, Szeged H-6725, Hungary.
Radiol Res Pract. 2021 Oct 15;2021:9499420. doi: 10.1155/2021/9499420. eCollection 2021.
Carotid bodies (CBs) play an important role in regulating sympathetic nervous system activity. Thus, they are likely to be enlarged in patients with certain cardiovascular and respiratory diseases. The aim of this case-control study was to verify this hypothesis using computed tomography angiography (CTA).
We retrospectively analysed 141 CTAs including 16 controls, 96 patients with only hypertension (HT), 12 with HT and previous acute myocardial infarction (AMI), 9 with HT and heart failure (HF), and 8 with HT and chronic obstructive pulmonary disease (COPD). We assessed the data using analysis of variance, with < 0.05 indicating significance.
CB average areas in the controls were 2.31 mm (right side (RS)) vs. 2.34 mm (left side (LS)). CB size was significantly enlarged in patients with HT: 3.07 mm (RS) (=0.019) vs. 2.91 mm (LS) (=0.002). If AMI (RS: 3.5 mm; LS: 3.44 mm) or HF (RS: 4.01 mm; LS: 4.55 mm) was associated with HT, the CB size was even more enlarged. COPD did not affect CB size (RS: 2.40 mm; LS: 2.29 mm).
Our data showed that certain diseases with increased activity of the sympathetic nervous system were associated with significantly enlarged CBs.
颈动脉体（CBs）在调节交感神经系统活动中起重要作用。因此，在某些心血管和呼吸系统疾病患者中，它们可能会增大。本病例对照研究的目的是使用计算机断层血管造影（CTA）验证这一假设。
我们回顾性分析了141例CTA，包括16例对照、96例仅患有高血压（HT）的患者、12例患有HT且曾有急性心肌梗死（AMI）的患者、9例患有HT且伴有心力衰竭（HF）的患者以及8例患有HT且伴有慢性阻塞性肺疾病（COPD）的患者。我们使用方差分析评估数据，P<0.05表示有统计学意义。
对照组中CB的平均面积右侧（RS）为2.31mm，左侧（LS）为2.34mm。HT患者的CB大小显著增大：右侧为3.07mm（P=0.019），左侧为2.91mm（P=0.002）。如果AMI（右侧：3.5mm；左侧：3.44mm）或HF（右侧：4.01mm；左侧：4.55mm）与HT相关，则CB大小增大更明显。COPD不影响CB大小（右侧：2.40mm；左侧：2.29mm）。
我们的数据表明，某些交感神经系统活动增强的疾病与CB显著增大有关。
