The Biotechnology & Drug Development Research Laboratory, Curtin Medical School & Curtin Health Innovation Research Institute, Curtin University, Bentley, 6102, Perth, Western Australia, Australia.
Hearing Therapeutics, The Ear Science Institute Australia, Queen Elizabeth II Medical Centre, Nedlands, 6009, Perth, Western Australia, Australia.
Ther Deliv. 2021 Oct;12(10):723-737. doi: 10.4155/tde-2021-0050. Epub 2021 Oct 26.
Advancement in the prevention of chemotherapy-induced hearing loss has proposed new nano-based delivery matrices that can target inner ear regions most damaged by chemotherapy. Chemotherapy agents (e.g., cisplatin) induce increased reactive oxygen species formation in the inner ear that damage sensory hair cells and result in irreversible hearing impairment. Exogenous antioxidants (e.g., Probucol and metformin) have been shown to block the formation of these reactive oxygen species. Delivery of these drugs in effective concentrations remains a challenge. Microencapsulation in combination with drug excipients provides one technique to effectively deliver these drugs. This paper investigates the use of probucol and metformin in combination with drug excipients for novel, inner ear, delivery.
在预防化疗引起的听力损失方面的进展提出了新的基于纳米的递药系统，这些系统可以靶向受化疗损伤最严重的内耳区域。化疗药物（如顺铂）在内耳中诱导产生更多的活性氧，这些活性氧会损伤感觉毛细胞，导致不可逆转的听力损伤。外源性抗氧化剂（如普罗布考和二甲双胍）已被证明可以阻止这些活性氧的形成。以有效浓度递送这些药物仍然是一个挑战。用药物辅料进行微囊化提供了一种有效递送这些药物的技术。本文研究了将普罗布考和二甲双胍与药物辅料联合用于内耳递药的新方法。
