接受体外膜肺氧合 (ECMO) 治疗的 COVID-19 患者的临床病程：韩国大邱的一项多中心研究。
Clinical course of COVID-19 patients treated with ECMO: A multicenter study in Daegu, South Korea.
机构信息
Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Hospital, Keimyung University College of Medicine, Daegu, Republic of Korea.
Department of Thoracic and Cardiovascular Surgery, Keimyung University Dongsan Hospital, Keimyung University College of Medicine, Daegu, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Keimyung University Daegu Dongsan Hospital, Keimyung University College of Medicine, Daegu, Republic of Korea.
出版信息
Heart Lung. 2021 Jan-Feb;50(1):21-27. doi: 10.1016/j.hrtlng.2020.10.010. Epub 2020 Oct 19.
BACKGROUND
The COVID-19 pandemic has caused an epidemic of critical patients, some of whom have been treated with extracorporeal membrane oxygenation (ECMO). This purpose of study is to describe the clinical course of COVID-19 patients treated with ECMO.
METHODS
A multicentered study of critical patients with COVID-19 treated at six hospitals in Daegu was conducted between January and April 2020.
RESULTS
Among the 80 patients receiving mechanical ventilation support, 19 (24%) were treated with ECMO included (median age 63.0 years). Eight of the 19 patients (42%) were weaned off ECMO (9.8 days, IQR 7.0-13.7). Among them, four patients were also weaned off mechanical ventilation (33.4 days, IQR 29.3 - 35.7), three were still receiving mechanical ventilation (50.9 days), and one expired after ECMO weaning. According to the univariate analysis, the factor that was associated with successful ECMO weaning was vitamin B12 treatment (p = 0.028).
CONCLUSIONS
During the COVID-19 epidemic, ECMO weaning and mortality rates were 42% and 58%, respectively.
背景
COVID-19 大流行导致危重症患者大量增加，其中一些患者接受了体外膜肺氧合（ECMO）治疗。本研究旨在描述接受 ECMO 治疗的 COVID-19 患者的临床病程。
方法
对 2020 年 1 月至 4 月期间在大邱的六家医院接受机械通气支持的 COVID-19 危重症患者进行了一项多中心研究。
结果
在接受机械通气支持的 80 名患者中，有 19 名（24%）接受 ECMO 治疗（中位年龄 63.0 岁）。在这 19 名患者中，有 8 名（42%）成功撤机（撤机时间为 9.8 天，IQR 7.0-13.7）。其中，4 名患者同时成功撤机机械通气（撤机时间为 33.4 天，IQR 29.3 - 35.7），3 名患者仍在接受机械通气（50.9 天），1 名患者在 ECMO 撤机后死亡。单因素分析显示，维生素 B12 治疗与 ECMO 成功撤机相关（p=0.028）。
结论
在 COVID-19 疫情期间，ECMO 撤机率和死亡率分别为 42%和 58%。
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