Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India.
Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru 570026, Karnataka, India.
Curr Issues Mol Biol. 2021 Oct 10;43(3):1502-1517. doi: 10.3390/cimb43030106.
Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.
染料木黄酮是一种大量存在于大豆中的异黄酮。由于具有广泛的生物活性，它正在被广泛研究以了解其抗癌作用。对其抗癌活性机制的研究揭示了许多途径，包括诱导细胞增殖、抑制酪氨酸激酶、调节 Hedgehog-Gli1 信号通路、调节表观遗传活性、阻断细胞周期以及 Akt 和 MEK 信号通路等，通过这些途径可以控制癌细胞增殖。然而，观察到的活性是时间和剂量依赖性的。此外，染料木黄酮在女性中的作用也因生理参数的不同而不同，如绝经前或绝经后状态。
