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聚（甲基丙烯酸 2-羟乙酯-co-N,N-二甲基丙烯酰胺）包覆的石英晶体微天平传感器：膜表征与概念验证

Poly(2-Hydroxyethyl methacrylate-co-N,N-dimethylacrylamide)-Coated Quartz Crystal Microbalance Sensor: Membrane Characterization and Proof of Concept.

作者信息

Hernandez-Martinez Angel Ramon

机构信息

Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Queretaro 76230, Queretaro, Mexico.

出版信息

Gels. 2021 Sep 24;7(4):151. doi: 10.3390/gels7040151.

DOI:10.3390/gels7040151
PMID:34698146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8544454/
Abstract

Application-oriented hydrogel properties can be obtained by modifying the synthesis conditions of the materials. The purpose of this study is to achieve customized properties for sensing applications of hydrogel membranes based on poly(2-hydroxyethyl methacrylate), HEMA and N,N-dimethylacrylamide, DMAa. Copolymer p(HEMA-co-DMAa) hydrogels were prepared by varying the DMAa monomer ratio from 0-100% in 20% increments. Hydrogel membranes were characterized by attenuated infrared spectroscopy. Swelling and sorption were evaluated using cation solutions. Copolymers were also synthesized on the gold surface of quartz crystal microbalances (QCM) as coating membranes. A proof of concept was conducted for approaching the design and development of QCM sensors based on P(DMAa-co-HEMA)-membranes. Results showed that the water and ion adsorption capacity of hydrogel membranes increased with higher DMAa content. Membranes are not selective to a specific location but did show different transport features with each cation. The QCM coated with the selected membrane presented linear relationships between resonance frequency and ions concentration in solution (10-120 ppm). As a consequence, hydrogel membranes obtained are promising for the development of future biosensing devices.

摘要

通过改变材料的合成条件可以获得面向应用的水凝胶特性。本研究的目的是实现基于聚甲基丙烯酸2-羟乙酯（HEMA）和N,N-二甲基丙烯酰胺（DMAa）的水凝胶膜传感应用的定制特性。通过以20%的增量将DMAa单体比例从0-100%变化来制备共聚物聚（HEMA-co-DMAa）水凝胶。用水凝胶膜通过衰减红外光谱进行表征。使用阳离子溶液评估溶胀和吸附。共聚物也作为涂层膜在石英晶体微天平（QCM）的金表面上合成。基于聚（DMAa-co-HEMA）膜对QCM传感器的设计和开发进行了概念验证。结果表明，水凝胶膜的水和离子吸附能力随着DMAa含量的增加而增加。膜对特定位置没有选择性，但对每种阳离子确实表现出不同的传输特征。涂有选定膜的QCM在共振频率和溶液中的离子浓度（10-120 ppm）之间呈现线性关系。因此，所获得的水凝胶膜有望用于未来生物传感装置的开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/9818005a3a5d/gels-07-00151-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/f9ad304c90e2/gels-07-00151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/20778a635680/gels-07-00151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/8b598513acc6/gels-07-00151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/bf59cc46d727/gels-07-00151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/1d5f961a531e/gels-07-00151-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/a4a622864e0c/gels-07-00151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/9818005a3a5d/gels-07-00151-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/f9ad304c90e2/gels-07-00151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/20778a635680/gels-07-00151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/8b598513acc6/gels-07-00151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/bf59cc46d727/gels-07-00151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/1d5f961a531e/gels-07-00151-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/a4a622864e0c/gels-07-00151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22f9/8544454/9818005a3a5d/gels-07-00151-g007.jpg

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