Thomson William Murray, Smith Moira B, Ferguson Catherine Anna, Moses Geraldine
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin 9054, New Zealand.
Department of Public Health, Wellington School of Medicine, Faculty of Medicine, University of Otago, Wellington 6021, New Zealand.
Pharmacy (Basel). 2021 Oct 1;9(4):162. doi: 10.3390/pharmacy9040162.
With a reported prevalence between 20% and 30%, dry mouth is more common among older people than any other age group. The major risk factor for dry mouth is polypharmacy. Older people take more medications than any other age group, not only for symptomatic relief of various age-associated chronic diseases, but also to reduce the likelihood of the complications that may arise from those conditions. Most aged care residents take even more medications than older people who are living in their own homes. The greater the number of medications taken, the greater the associated anticholinergic burden, and the more likely it is that the individual will suffer from dry mouth. The condition not only affects the dentition and ability to wear dentures, but also the sufferers' quality of life. Treating dry mouth is a considerable challenge for clinicians. As medication use is by far the most important risk factor, there is a need for pharmacists, doctors and dentists to work together to prevent this from occurring. Medication review and deprescribing is a key strategy, but there have not yet been any randomised control trials of its efficacy in reducing the occurrence of dry mouth.
据报道,口干的患病率在20%至30%之间,在老年人中比其他任何年龄组都更常见。口干的主要风险因素是多重用药。老年人服用的药物比其他任何年龄组都多,不仅用于缓解各种与年龄相关的慢性病的症状,还用于降低这些疾病可能引发的并发症的可能性。大多数老年护理机构的居民服用的药物甚至比住在自己家里的老年人更多。服用的药物数量越多,相关的抗胆碱能负担就越大,个体患口干的可能性就越高。这种情况不仅会影响牙列和佩戴假牙的能力,还会影响患者的生活质量。治疗口干对临床医生来说是一项相当大的挑战。由于用药是迄今为止最重要的风险因素,因此药剂师、医生和牙医需要共同努力以防止这种情况发生。药物审查和减药是一项关键策略,但尚未有关于其减少口干发生率疗效的随机对照试验。