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岭南火针联合0.1%透明质酸钠滴眼液治疗干眼症的随机对照试验

[Lingnan fire needling combined with 0.1% sodium hyaluronate eye drops in the treatment of xerophthalmia: a randomized controlled trial].

作者信息

Liu Hong, Teng Yue, Yu Xiao-Yi, Li Jun-Hui, Chen Yan-Jun, Li Jian-Hong, Lin Guo-Hua

机构信息

Ophthalmology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510540, China; The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510540.

Ophthalmology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510540, China.

出版信息

Zhen Ci Yan Jiu. 2021 Oct 25;46(10):863-8. doi: 10.13702/j.1000-0607.200960.

Abstract

OBJECTIVE

To observe the effect of Lingnan fire needling combined with artificial tears in the treatment of xerophthalmia.

METHODS

A total of 86 xerophthalmia patients were equally and randomly divided into treatment group and control group. The patients of both groups were received treatment with 0.1% sodium hyaluronate eye drops in their eyes 3 times a day, one drop in each eye. In addition, the patients of treatment group also treated by Lingnan fire needling on bilateral Shaoze (SI1), Neichengqi and beside lacrimal puncta once a week. The treatment was conducted for 4 consecutive weeks. Before and after 4 weeks of treatment, the clinical efficacy, visual acuity, intraocular pressure, ocular symptom score, OSDI score, fluorescence staining (FL) score, schemer I, tear menisci height, tear film break-up time (BUT) and eye redness index were recorded and evaluated.

RESULTS

After the treatment, self-comparison showed that the symptom score, OSDI score, FL score and eye redness index were significantly decreased (<0.05), and BUT was notably increased in both groups (<0.05) in comparison with their own pre-treatment. The tear menisci height in the treatment group was higher than that before the treatment (<0.05). Comparison between the two groups showed that the symptom score, OSDI score and eye redness index were obviously lower in the treatment group than in the control group (<0.05), whereas the BUT and tear menisci height were evidently higher (<0.05). The total effective rate of the treatment group was 84.88% (73/86), better than 76.74% (66/86) of the control group (<0.05).

CONCLUSION

Lingnan fire needling combined with 0.1% sodium hyaluronate eye drops is more effective than simple sodium hyaluronate eye drops for xerophthalmia patients, with significant curative effect and no adverse reactions.

摘要

目的

观察岭南火针联合人工泪液治疗干眼症的效果。

方法

将86例干眼症患者随机等分为治疗组和对照组。两组患者均使用0.1%透明质酸钠滴眼液滴眼,每日3次,每眼1滴。此外,治疗组患者还每周接受1次岭南火针治疗双侧少泽穴(SI1)、内承泣穴及泪小点旁。连续治疗4周。记录并评估治疗4周前后的临床疗效、视力、眼压、眼部症状评分、干眼特异性问卷(OSDI)评分、荧光素染色(FL)评分、泪河I型、泪膜破裂时间(BUT)和眼红指数。

结果

治疗后,两组自身比较显示,症状评分、OSDI评分、FL评分和眼红指数均显著降低(<0.05),BUT较治疗前显著增加(<0.05)。治疗组泪河高度高于治疗前(<0.05)。两组间比较显示,治疗组症状评分、OSDI评分和眼红指数明显低于对照组(<0.05),而BUT和泪河高度明显高于对照组(<0.05)。治疗组总有效率为84.88%(73/86),优于对照组的76.74%(66/86)(<0.05)。

结论

岭南火针联合0.1%透明质酸钠滴眼液治疗干眼症患者比单纯使用透明质酸钠滴眼液更有效,疗效显著且无不良反应。

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