Lin Zhong-Si, Yu Dong-Song, Zhao Jin-Long, Shi Hui-Yang, Zhang Zhu-Qiang, Zhao Lei, Ju Pin
Shandong College of TCM, Yantai 264199, China.
Department of Ophthalmology, Second Affiliated Hospital of Liaoning University of TCM.
Zhongguo Zhen Jiu. 2022 Dec 12;42(12):1379-83. doi: 10.13703/j.0255-2930.20220318-0001.
On the basis of sodium hyaluronate eye drops, to observe the clinical efficacy of acupuncture on dry eye and explore the effect mechanism of ocular surface protection.
A total of 80 patients with dry eye were randomly divided into an observation group and a control group, 40 cases in each group. The control group was treated with routine cleaning of eyelid margin, hot compress of eyes with warm towel, and external application of sodium hyaluronate eye drops for 5 weeks. On the basis of the treatment as the control group, the observation group was treated with acupuncture at Jingming (BL 1), Cuanzhu (BL 2), Chengqi (ST 1), Hegu (LI 4), Zusanli (ST 36), Sanyinjiao (SP 6), etc., once a day, 6 times a week for 5 weeks (30 times totally). Before and after treatment, SchirmerⅠtest (SⅠT), breaking up time (BUT), corneal fluorescent (FL) score, ocular surface disease index (OSDI) score, and the contents of IL-6 and TNF-α in tears were evaluated and the therapeutic effect was compared between the two groups.
Compared with before treatment, SⅠT and BUT after treatment in the observation group were prolonged (<0.05), the scores of FL and OSDI and the contents of IL-6 and TNF-α in tears were decreased (<0.05). After treatment, SⅠT and BUT in the observation group were longer than the control group (<0.05), and the scores of FL and OSDI and the contents of IL-6 and TNF-α in tears in the observation group were lower than the control group (<0.05). The total effective rate in the observation group was 87.5% (35/40), which was higher than 45.0% (18/40) in the control group (<0.05).
On the basis of sodium hyaluronate eye drops, acupuncture could improve the clinical symptoms of dry eye, promote the secretion of tears, prolong the tear film breaking up time, and reduce corneal damage, and effect mechanism may be related to the reduction of inflammatory response.
在玻璃酸钠滴眼液的基础上，观察针刺治疗干眼症的临床疗效，探讨其眼表保护作用机制。
将80例干眼症患者随机分为观察组和对照组，每组40例。对照组采用常规睑缘清洁、温毛巾热敷眼部，并外用玻璃酸钠滴眼液治疗5周。观察组在对照组治疗的基础上，针刺睛明（BL 1）、攒竹（BL 2）、承泣（ST 1）、合谷（LI 4）、足三里（ST 36）、三阴交（SP 6）等穴位，每日1次，每周6次，共治疗5周（共30次）。治疗前后分别评估泪液分泌试验（SⅠT）、泪膜破裂时间（BUT）、角膜荧光素（FL）染色评分、眼表疾病指数（OSDI）评分以及泪液中白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的含量，并比较两组的治疗效果。
与治疗前比较，观察组治疗后SⅠT延长、BUT延长（<0.05），FL染色评分、OSDI评分以及泪液中IL-6和TNF-α的含量降低（<0.05）。治疗后，观察组的SⅠT和BUT长于对照组（<0.05），观察组的FL染色评分、OSDI评分以及泪液中IL-6和TNF-α的含量低于对照组（<0.05）。观察组总有效率为87.5%（35/40），高于对照组的45.0%（18/40）（<0.05）。
在玻璃酸钠滴眼液基础上，针刺可改善干眼症临床症状，促进泪液分泌，延长泪膜破裂时间，减轻角膜损伤，其作用机制可能与减轻炎症反应有关。
