Department of Spine, The First Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Department of Chinese and Western Integrative Medicine, Hunan Brain Hospital, Clinical Medical School, Hunan University of Chinese Medicine, Changsha, People's Republic of China.
J Spinal Cord Med. 2023 Jan;46(1):99-106. doi: 10.1080/10790268.2021.1954378. Epub 2021 Oct 26.
Spinal cord injury (SCI) refers to the interruption of the tracts inside the spinal cord caused by various factors. The repair of damaged axons has always been a difficult point in clinical treatment and neuroscience research. The treatment of SCI with Buyang huanwu decoction (BYHWD), a well-known recipe for invigorating Qi (a vital force forming part of any living entity in traditional Chinese culture) and promoting blood circulation, shows a good effect.
The rubrospinal tract (RST) transection model in rats was established in this study and rats were administrated with low (BL), medium (BM), or high (BH) doses of BYHWD.
Compared with the SCI group, BL, BM moderately, and BH significantly improved the motor function of forelimbs and increased the number of red nucleus neurons in SCI rats. As for the possible molecular mechanism, BL, BM moderately, and BH significantly increased mTOR whereas decreased Beclin-1 and LC3 in the red nucleus.
In conclusion, low, medium, and high doses of BYHWD could promote neural recovery in SCI rats through improving motor function and neuron survival in the red nucleus. The neuroprotective effects of BYHWD might be associated with affecting the mTOR signaling pathway and autophagy.
脊髓损伤（SCI）是指各种因素导致的脊髓内束中断。受损轴突的修复一直是临床治疗和神经科学研究的难点。补阳还五汤（BYHWD）是一种益气活血的著名方剂，用于治疗 SCI 具有良好的效果。
本研究建立了大鼠红核脊髓束（RST）横断模型，并给予大鼠低（BL）、中（BM）、高（BH）剂量的 BYHWD。
与 SCI 组相比，BL、BM 适度，BH 显著改善了 SCI 大鼠前肢的运动功能，并增加了红核神经元的数量。至于可能的分子机制，BL、BM 适度和 BH 显著增加了 mTOR，而降低了红核中的 Beclin-1 和 LC3。
总之，低、中、高剂量的 BYHWD 可通过改善运动功能和红核神经元存活来促进 SCI 大鼠的神经恢复。BYHWD 的神经保护作用可能与影响 mTOR 信号通路和自噬有关。
