纳米胶束增强的不对称 ERED 催化活化烯烃的还原反应。在水中一锅法化学和生物催化序列中的应用。
Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water.
机构信息
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.
Novartis Pharma AG, CH-4057 Basel, Switzerland.
出版信息
Chem Commun (Camb). 2021 Nov 9;57(89):11847-11850. doi: 10.1039/d1cc04774d.
PMID:34698744
Abstract
Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.
摘要
在水相体系中，通过表面活性剂 TPGS-750-M 衍生的纳米胶束与化学催化相偶联，可以极大地增强涉及烯还原酶（EREDs）的生物催化反应。本文提供了一些转化实例，说明了在 1 锅中实现多种序列的可能性，这些实例代表了这种对环境友好的有机合成方法的新进展。
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