Department of Internal Medicine, College of Medicine, Jouf University, Saudi Arabia.
Dr. Salma Center for Kidney Diseases, University of Khartoum, Khartoum, Sudan.
Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102320. doi: 10.1016/j.dsx.2021.102320. Epub 2021 Oct 20.
Limited data are available regarding the risk factors associated with the development of diabetic kidney disease (DKD) among Sudanese adults with type 2 diabetes mellitus (T2DM).
A case-control study was conducted at Dr. Salma Center for Kidney Diseases between April and September 2019. Patients with T2DM and DKD were compared to age and sex-matched T2DM patients with no kidney disease (NKD). Socio-demographic features, clinical findings, and laboratory investigations of the study subjects and controls were analyzed using SPSS.
A total of 372 patients with DKD were compared to 364 T2DM patients with NKD. The mean age of the DKD patients was 58 ± 13.4 years, their median eGFR was 37.3 ± 4.9 ml/min/1.73 m; they had their T2DM at a significantly younger age compared to controls (P = 0.014). Logistic regression analysis revealed that a family history of diabetes mellitus, a family history of chronic kidney disease, the presence of hypertension, obesity, hypercholesterolemia, hyperuricemia, smoking, recurrent urinary tract infection, and the regular use of non-steroidal anti-inflammatory drugs were significantly associated with the development of DKD (P values < 0.05).
A series of modifiable risk factors were found to be significant determinants for developing DKD. Primary care physicians are expected to pay considerable attention to their control.
有关苏丹 2 型糖尿病（T2DM）患者中与糖尿病肾脏疾病（DKD）发展相关的危险因素的数据有限。
2019 年 4 月至 9 月在 Dr. Salma 肾脏疾病中心进行了一项病例对照研究。将 T2DM 伴 DKD 患者与年龄和性别匹配的无肾脏疾病（NKD）T2DM 患者进行比较。使用 SPSS 分析研究对象和对照组的社会人口统计学特征、临床发现和实验室检查结果。
共比较了 372 例 DKD 患者和 364 例 T2DM 伴 NKD 患者。DKD 患者的平均年龄为 58±13.4 岁，中位 eGFR 为 37.3±4.9 ml/min/1.73 m；与对照组相比，他们的 T2DM 发病年龄明显较小（P=0.014）。Logistic 回归分析显示，糖尿病家族史、慢性肾脏病家族史、高血压、肥胖、高胆固醇血症、高尿酸血症、吸烟、复发性尿路感染和非甾体抗炎药的常规使用与 DKD 的发生显著相关（P 值<0.05）。
一系列可改变的危险因素被发现是 DKD 发展的重要决定因素。初级保健医生预计将非常关注这些危险因素的控制。
