重新思考罕见病：通过X连锁非整倍体寻找延长寿命的药物靶点。
Rethinking rare disease: longevity-enhancing drug targets through X-linked aneuploidy.
作者信息
Taylor-King Jake P
机构信息
Relation Therapeutics, London, UK; Juvenescence Ltd., London, UK.
出版信息
Trends Genet. 2022 Apr;38(4):317-320. doi: 10.1016/j.tig.2021.10.006. Epub 2021 Oct 23.
PMID:34702579
Abstract
Complex diseases, including ageing, often exhibit sexual dimorphism. These sex differences can obfuscate attribution to causal genes within a target ID campaign. Mendelian randomisation (MR)-inspired analysis provides a natural setting to incorporate X-linked aneuploid populations, resulting in prioritisation of longevity-enhancing drug targets and motivating greater inclusion of said populations in future profiling studies.
摘要
包括衰老在内的复杂疾病通常表现出性别二态性。这些性别差异可能会混淆目标识别活动中对因果基因的归因。受孟德尔随机化（MR）启发的分析提供了一个自然的环境来纳入X连锁非整倍体群体，从而确定延长寿命的药物靶点的优先级，并促使在未来的分析研究中更多地纳入这些群体。
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