Manchanda Adesh S, Narang Ramandeep Singh, Mahajan Sanah
Department of Oral and Maxillofacial Pathology and Microbiology, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.
Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.
J Oral Maxillofac Pathol. 2021 May-Aug;25(2):374-375. doi: 10.4103/0973-029X.325264. Epub 2021 Aug 31.
Osteosarcoma (OS) comprises 2.1% of all malignant oral and maxillofacial tumors. OS arising from the jaw OS differs from OS of the long bones in its biological behavior, presenting a lower incidence of metastasis and a better prognosis. The morphologic and behavioral heterogeneity observed in OS and the perplexity of the varied histological features mimicking other primary and metastatic bone tumors has emphasized the need of advanced molecular techniques in its diagnosis. Hereby, we present a case of OS which was diagnosed by immunohistochemical analysis, aiding in establishing its histogenetic origin.
骨肉瘤(OS)占所有口腔颌面部恶性肿瘤的2.1%。颌骨骨肉瘤在生物学行为上不同于长骨骨肉瘤,其转移发生率较低,预后较好。骨肉瘤中观察到的形态学和行为异质性以及模仿其他原发性和转移性骨肿瘤的各种组织学特征的复杂性,凸显了先进分子技术在其诊断中的必要性。在此,我们报告一例通过免疫组化分析诊断的骨肉瘤病例,有助于确定其组织发生来源。