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富含巨细胞的骨肉瘤——1例罕见病例。

Giant cell-rich osteosarcoma - A rare case.

作者信息

Mallick Aishika, Shah Neha, Mahmud Sk Abdul, Das Sanjeet Kumar

机构信息

Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

出版信息

J Oral Maxillofac Pathol. 2020 Feb;24(Suppl 1):S67-S72. doi: 10.4103/jomfp.JOMFP_251_19. Epub 2020 Feb 28.

DOI:10.4103/jomfp.JOMFP_251_19
PMID:32189908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7069131/
Abstract

Giant cell-rich osteosarcoma (GCRO) is an exceedingly rare histological variant of conventional primary osteosarcoma. It constitutes about 1%-3% of all osteosarcomas, and is extremely uncommon in the maxillofacial region. The unusual histopathological appearance and the rarity of the lesion poses a great diagnostic challenge. This article aims to present a rare case of GCRO involving the mandible in a 52-year-old male patient.

摘要

富含巨细胞的骨肉瘤（GCRO）是传统原发性骨肉瘤中一种极为罕见的组织学变体。它约占所有骨肉瘤的1%-3%，在颌面部极为罕见。这种不寻常的组织病理学表现以及该病变的罕见性给诊断带来了巨大挑战。本文旨在介绍一例罕见的GCRO病例，该病例发生在一名52岁男性患者的下颌骨。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/8ef1dc57bf13/JOMFP-24-67-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/5d1cbfa1784c/JOMFP-24-67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/03b0bafece8b/JOMFP-24-67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/b6d2e84835fb/JOMFP-24-67-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/644135b15b5a/JOMFP-24-67-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/aa5cecaaac57/JOMFP-24-67-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/8ef1dc57bf13/JOMFP-24-67-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/5d1cbfa1784c/JOMFP-24-67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/03b0bafece8b/JOMFP-24-67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/b6d2e84835fb/JOMFP-24-67-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/644135b15b5a/JOMFP-24-67-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/aa5cecaaac57/JOMFP-24-67-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e699/7069131/8ef1dc57bf13/JOMFP-24-67-g006.jpg

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本文引用的文献

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2
Gnathic giant-cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification.伴有MDM2和CDK4基因扩增的颌骨富含巨细胞的传统型骨肉瘤
Histopathology. 2017 Jun;70(7):1171-1173. doi: 10.1111/his.13141. Epub 2017 Mar 22.
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Giant cell rich osteosarcoma revisited-diagnostic criteria and histopathologic patterns, Ki67, CDK4, and MDM2 expression, changes in response to bisphosphonate and denosumab treatment.
一只家养短毛猫的椎骨骨巨细胞瘤。
JFMS Open Rep. 2023 Apr 11;9(1):20551169231160227. doi: 10.1177/20551169231160227. eCollection 2023 Jan-Jun.
4
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J Oral Maxillofac Pathol. 2021 May-Aug;25(2):374-375. doi: 10.4103/0973-029X.325264. Epub 2021 Aug 31.
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Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.Serglycin 诱导破骨细胞生成并促进骨巨细胞瘤生长。
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Virchows Arch. 2016 Jun;468(6):741-55. doi: 10.1007/s00428-016-1926-9. Epub 2016 Mar 22.
4
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