Etemadzadeh H, Ainamo J
J Clin Periodontol. 1987 Mar;14(3):176-80. doi: 10.1111/j.1600-051x.1987.tb00963.x.
The aim of the study was to compare the anti-plaque effect of sanguinaria extract to that of a known effective agent, chlorhexidine gluconate, and to that of a known ineffective agent, tap water. The study was conducted as a 3 times crossed-over and blindly evaluated 3 week clinical trial. 12 dental students rinsed in an individually randomized sequence twice daily for 4 days (Monday to Friday) with Viadent containing 0.03% sanguinaria extract (0.01% sanguinarine chloride) and a 1000 ppm concentration of zinc ions (ZnCl2), 2 X 30 s X 10 ml; with Hibitane Dental containing 0.2% chlorhexidine gluconate, 1 min X 10 ml; and with tap water, 1 min X 10 ml. Mechanical oral hygiene was allowed only during the 3 days between test periods. When measured according to the plaque index or in terms of plaque wet weight, only the chlorhexidine rinse further reduced the low Monday scores. No significant difference was observed between Friday scores after rinses with Viadent and water. The variation in effect of the 3 rinses was less marked when assessed by means of area of plaque on the tooth surfaces. Subjectively, both the taste and effect of Viadent was reported to be poor. In a second controlled clinical trial using the same design, no significant difference in anti-plaque effect was found between the commercially available Viadent rinse and an experimental rinse with a tripled concentration of sanguinarine chloride but the same content of zinc.
该研究的目的是比较血根碱提取物与已知有效药物葡萄糖酸氯己定以及已知无效药物自来水的抗牙菌斑效果。该研究采用3次交叉设计，并进行了为期3周的盲法评估临床试验。12名牙科学生按照个体随机顺序，每天两次（周一至周五），连续4天分别用含有0.03%血根碱提取物（0.01%氯化血根碱）和1000 ppm锌离子（ZnCl2）的Viadent漱口水（2次，每次30秒，每次10毫升）、含有0.2%葡萄糖酸氯己定的Hibitane Dental漱口水（1分钟，每次10毫升）以及自来水（1分钟，每次10毫升）进行漱口。仅在测试期之间的3天允许进行机械口腔卫生清洁。根据菌斑指数或菌斑湿重测量时，只有氯己定漱口水进一步降低了周一的低得分。用Viadent漱口水和水漱口后周五的得分之间未观察到显著差异。当通过牙齿表面菌斑面积评估时，三种漱口水效果的差异不太明显。主观上，据报告Viadent漱口水的味道和效果都很差。在使用相同设计的第二项对照临床试验中，市售的Viadent漱口水与氯化血根碱浓度增加两倍但锌含量相同的实验性漱口水之间在抗牙菌斑效果上未发现显著差异。
