Mahjoub Ahmed, Cherni Ines, Khayrallah Oumayma, Ben Abdesslam Nadia, Mahjoub Anis, Anas Romdhane, Ghorbel Mohamed, Mahjoub Hachmi, Knani Leila, Krifa Fethi
Department of Ophtalmology, Farhat Hached Hospital, Sousse, Tunisia.
Ann Med Surg (Lond). 2021 Oct 1;70:102904. doi: 10.1016/j.amsu.2021.102904. eCollection 2021 Oct.
Diabetic retinopathy (DR) increases the risk of blindness by 25 times. Advanced researchs are justified for better management, leading to the role of Optical Coherence Tomography-Angiography (OCT-A), a new non-invasive imaging technique exploring retinal vascularization.Our purpose is to identify microvascular macular anomalies of DR on OCT-A with qualitative and quantitative evaluation of their impact on retinal vascularization.
This is a descriptive cross-sectional study where 120 eyes of 66 diabetic patients were enrolled. All patients were diabetic and went through OCT-A imaging.
Microanevrysms were identified in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) where they were more frequently visualized. Macular edema was present in 16,7% of cases in the SCP, and in 30% in DCP. Edema spaces were more frequently present in DCP (p < 0,05). Capillary nonperfusion areas were identified in 82,5% of cases in SCP and in 60% of cases in DCP. The main peri-foveal vascular density was 18,95 ± 5,37%. The main surface of foveal avascular zone (FAZ) in the SCP was 462,52 μm and was 555,04 ± 329,11 μm in the DCP where it was larger.
OCT-A is a modern imaging tool that could be used for the diagnosis and monitoring of DR as well as the understanding of its pathophysiology.
糖尿病视网膜病变（DR）使失明风险增加25倍。开展深入研究对于更好地管理该病是合理的，这促使光学相干断层扫描血管造影（OCT-A）发挥作用，它是一种探索视网膜血管化的新型非侵入性成像技术。我们的目的是通过对DR患者黄斑部微血管异常对视网膜血管化影响的定性和定量评估，来识别这些异常。
这是一项描述性横断面研究，纳入了66例糖尿病患者的120只眼。所有患者均为糖尿病患者，并接受了OCT-A成像检查。
在浅表毛细血管丛（SCP）和深部毛细血管丛（DCP）中均发现了微动脉瘤，且在DCP中更常见。SCP中16.7%的病例存在黄斑水肿，DCP中为30%。水肿间隙在DCP中更常见（p<0.05）。SCP中82.5%的病例和DCP中60%的病例存在毛细血管无灌注区。中心凹周围主要血管密度为18.95±5.37%。SCP中中心凹无血管区（FAZ）的主要面积为462.52μm²，DCP中为555.04±329.11μm²，DCP中的FAZ更大。
OCT-A是一种现代成像工具，可用于DR的诊断和监测以及对其病理生理学的理解。
