School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao City, China.
Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao City, China.
Invest Ophthalmol Vis Sci. 2023 Sep 1;64(12):21. doi: 10.1167/iovs.64.12.21.
The purpose of this study was to investigate the association between foveal vessels and retinal thickness in individuals with diabetic retinopathy (DR) and control subjects, and to reveal foveal avascular zone (FAZ) growth in early individuals with DR.
The regions with a thickness less than 60 µm were marked from the intima thickness maps and named FAZThic. The avascular zones extracted from the deep vascular plexus were designated as FAZAngi. The boundary of the two FAZ forms a ring region, which we called FAZRing. The FAZ growth rate was defined as the ratio of the FAZRing area to the FAZThic area. Thirty healthy controls and 30 individuals with mild nonproliferative DR were recruited for this study.
The FAZThic area in individuals with mild DR and control subjects showed similar distribution. The FAZAngi area in individuals with mild DR are higher than that in control subjects on the whole, but there was no significant difference (P > 0.05). The FAZRing area in individuals with mild DR was significantly higher than that in control subjects (P < 0.001). However, there is still a small amount of overlap data between the two groups. For the FAZ growth rate, the individuals with mild DR were also significantly larger than the control subjects (P < 0.001). But there were no overlapping data between the two groups.
The growth of FAZ in individuals with mild DR can be inferred by comparing FAZAngi with FAZThic. This method minimizes the impact of individual variations and helps researchers to understand the progression mechanism of DR more deeply.
本研究旨在探讨糖尿病视网膜病变（DR）患者和对照组个体的中心凹血管与视网膜厚度之间的关系，并揭示早期 DR 个体的中心凹无血管区（FAZ）的生长情况。
从内膜厚度图中标记厚度小于 60µm 的区域，并将其命名为 FAZThic。从深层血管丛中提取的无血管区被指定为 FAZAngi。这两种 FAZ 形式的边界形成一个环形区域，我们称之为 FAZRing。FAZ 生长率定义为 FAZRing 区域与 FAZThic 区域的比值。本研究共招募了 30 名健康对照者和 30 名轻度非增生性 DR 患者。
轻度 DR 患者和对照组个体的 FAZThic 区域分布相似。轻度 DR 患者的 FAZAngi 区域总体上高于对照组，但无显著差异（P>0.05）。轻度 DR 患者的 FAZRing 区域明显高于对照组（P<0.001）。然而，两组之间仍有少量重叠数据。对于 FAZ 生长率，轻度 DR 患者也明显大于对照组（P<0.001）。但两组之间没有重叠数据。
通过比较 FAZAngi 与 FAZThic，可以推断出轻度 DR 患者 FAZ 的生长情况。这种方法最大限度地减少了个体差异的影响，有助于研究人员更深入地了解 DR 的进展机制。
