Department of Paediatric Oncology and Haematology, Starship Children's Health, Auckland, New Zealand.
Liggins Institute, University of Auckland, Auckland, New Zealand.
Cancer Rep (Hoboken). 2022 Jul;5(7):e1534. doi: 10.1002/cnr2.1534. Epub 2021 Oct 26.
No international standards include vitamin D levels at diagnosis or during treatment. It is included in the Children's Oncology Group long-term follow-up guidelines. However, bone health complications (like osteopenia and atraumatic fractures) can occur at diagnosis or during treatment as well.
In this small case series, we illustrate the complexity of bone health complications among our broad paediatric oncology population. If the vitamin D level is low we supplement the patient with one standard oral dose (150 000 units for 1-2 year olds, 300 000 units for 2-5 year olds and 600 000 units for >5 year olds). We do not adjust depending on diagnosis.
Because of the potentially negative outcomes on short, medium and long term, we recommend checking vitamin D levels on diagnosis for all newly diagnosed patients. It is a simple, low cost test and one dose of oral supplementation can easily treat the deficiency.
目前尚无国际标准包括诊断时或治疗期间的维生素 D 水平。儿童肿瘤学组的长期随访指南中包含了这一标准。然而，骨质健康并发症（如骨质疏松和非外伤性骨折）也可能在诊断时或治疗期间发生。
在本小型病例系列中，我们展示了广泛儿科肿瘤患者中骨质健康并发症的复杂性。如果维生素 D 水平较低，我们会给患者补充一个标准口服剂量（1-2 岁儿童 150000 单位，2-5 岁儿童 300000 单位，>5 岁儿童 600000 单位）。我们不根据诊断进行调整。
由于短期、中期和长期可能产生负面后果，我们建议所有新诊断的患者在诊断时检查维生素 D 水平。这是一个简单、低成本的检测方法，一剂口服补充剂即可轻松治疗缺乏症。
