Revuelta Iniesta R, Rush R, Paciarotti I, Rhatigan E B, Brougham F H M, McKenzie J M, Wilson D C
Dietetics, Nutrition and Biological Health Sciences, Queen Margaret University, Edinburgh, UK; Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.
Dietetics, Nutrition and Biological Health Sciences, Queen Margaret University, Edinburgh, UK.
Clin Nutr. 2016 Feb;35(1):95-108. doi: 10.1016/j.clnu.2014.12.023. Epub 2015 Jan 16.
Vitamin D inadequacy is now an internationally recognized health problem and pediatric cancer patients may be at even higher risk than healthy children. We aimed to evaluate primary research to establish the prevalence of vitamin D inadequacy and to explore its possible causes in pediatric cancer patients.
Electronic databases were searched (no restriction-Aug 2013) with no language restrictions and keywords related to cancer and vitamin D. We included studies of patients aged <18 years, diagnosed with and treated for cancer and reporting plasma vitamin D status. Evidence was critically appraised employing the CASP tool. Meta-analysis was performed when appropriate.
We included 19 studies, which were mainly of moderate-quality and heterogeneous in the definitions of vitamin D deficiency and insufficiency. The median (range) prevalence of vitamin D deficiency was 14% (0-61.5%) and insufficiency 23% (0-83%). Finally, a significant effect of younger age with vitamin D inadequacy was shown (effect size: -0.132; 95%CI -0.203, -0.060).
There is a possibility of a high prevalence of vitamin D inadequacy in pediatric cancer patients, especially older children, urging the need for high-quality population-based longitudinal studies using standard definitions.
维生素D缺乏如今是一个国际公认的健康问题，儿科癌症患者可能比健康儿童面临更高的风险。我们旨在评估初步研究，以确定儿科癌症患者维生素D缺乏的患病率，并探究其可能的原因。
检索电子数据库（无限制——2013年8月），无语言限制，使用与癌症和维生素D相关的关键词。我们纳入了年龄小于18岁、被诊断患有癌症并接受治疗且报告血浆维生素D状况的患者研究。采用CASP工具对证据进行严格评估。在适当的时候进行荟萃分析。
我们纳入了19项研究，这些研究质量大多为中等，在维生素D缺乏和不足的定义方面存在异质性。维生素D缺乏的中位（范围）患病率为14%（0 - 61.5%），不足为23%（0 - 83%）。最后，结果显示年龄较小与维生素D缺乏之间存在显著关联（效应大小：-0.132；95%置信区间 -0.203，-0.060）。
儿科癌症患者，尤其是年龄较大的儿童，维生素D缺乏的患病率可能较高，这促使需要开展基于高质量人群的纵向研究，并使用标准定义。
