Madaeva I M, Berdina O N, Ukhinov E B, Kurashova N A, Semenova N V, Bairova T A, Bel'skikh A V, Natyaganova L V, Kolesnikov S I, Kolesnikova L I
Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2021 Oct;171(6):713-715. doi: 10.1007/s10517-021-05301-5. Epub 2021 Oct 27.
Serum serotonin levels were determined by HPLC in 30 patients with diagnosed obstructive sleep apnea syndrome before and after 3-month course of PAP-therapy and in 14 subjects without obstructive sleep apnea symptoms. It was found that elimination of hypoxic conditions was associated with an increase in serotonin level. The results demonstrate the effectiveness of PAP-therapy during sleep and allow assessing the role of serotonin as a potential biomarker of intermittent hypoxia during sleep.
采用高效液相色谱法测定了30例确诊为阻塞性睡眠呼吸暂停综合征的患者在接受3个月持续气道正压通气（PAP）治疗前后以及14例无阻塞性睡眠呼吸暂停症状受试者的血清5-羟色胺水平。结果发现，消除缺氧状态与5-羟色胺水平升高有关。这些结果证明了睡眠期间PAP治疗的有效性，并有助于评估5-羟色胺作为睡眠期间间歇性缺氧潜在生物标志物的作用。
