Bisatto Natália V, Crescente Betina B, Fritscher Guilherme G, Campos Maria M
Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Oral Maxillofac Surg. 2025 Jan 10;29(1):28. doi: 10.1007/s10006-025-01333-7.
It has been suggested that dentofacial deformities (DFD) can impair sleep quality. This pilot study aimed at evaluating sleep disorders in individuals with DFD before orthognathic surgery, correlating the clinical findings with salivary biomarker levels.
This cross-sectional study enrolled ten males and ten females with DFD diagnoses under orthodontic treatment preceding orthognathic surgery. The participants responded to the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Fletcher and Luckett Sleep Questionnaire (FLSQ). Obstructive sleep apnea (OSA) was examined by the Home Sleep Apnea Test (HSAT). The salivary levels of interleukin-1β (IL-1β), glutamate, and serotonin were measured.
85% of individuals presented PSQI and FLSQ scores indicative of sleep alterations. Females had higher scores in part 2 of the FLSQ instrument, referring to sleepiness-associated complaints. HSAT analysis revealed a low number of symptomatic OSA individuals, with three males demonstrating altered oxygen desaturation rates. There was a significant negative correlation between the salivary levels of serotonin and the FLSQ results.
Individuals with DFD diagnosis showed poorer sleep quality, which is likely independent of sex and OSA diagnosis, and negatively correlated with salivary levels of serotonin.
有人提出牙颌面畸形（DFD）会损害睡眠质量。这项初步研究旨在评估正颌手术前DFD患者的睡眠障碍，将临床结果与唾液生物标志物水平相关联。
这项横断面研究纳入了10名男性和10名女性，他们在正颌手术前接受正畸治疗，被诊断为DFD。参与者回答了匹兹堡睡眠质量指数（PSQI）、爱泼华嗜睡量表（ESS）以及弗莱彻和勒基特睡眠问卷（FLSQ）。通过家庭睡眠呼吸暂停测试（HSAT）检查阻塞性睡眠呼吸暂停（OSA）。测量唾液中白细胞介素-1β（IL-1β）、谷氨酸和血清素的水平。
85%的个体PSQI和FLSQ评分表明存在睡眠改变。女性在FLSQ量表第二部分的得分较高，该部分涉及与嗜睡相关的主诉。HSAT分析显示有症状的OSA个体数量较少，有三名男性的氧饱和度下降率发生改变。血清素唾液水平与FLSQ结果之间存在显著负相关。
被诊断为DFD的个体睡眠质量较差，这可能与性别和OSA诊断无关，且与血清素唾液水平呈负相关。
