Medical Center for Dementia, University Hospital, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-Ku, Kitakyushu, Fukuoka, 8078555, Japan.
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
Cerebellum. 2022 Dec;21(6):1135-1138. doi: 10.1007/s12311-021-01338-4. Epub 2021 Oct 27.
Depressive state is a common complication of spinocerebellar ataxia type 3 (SCA3). To the best of our knowledge, cases of SCA3 presenting with cenesthopathy have not been described. Here, we present a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. A 43-year-old Japanese man with SCA3 developed a severe depressive state with associated cenesthopathy and delusion. He was treated with escitalopram (10 mg/day) and olanzapine (2.5 mg/day). Computed tomography showed atrophy of the cerebellum, bilateral superior cerebellar peduncle, and tegmentum of the pons. Single-photon emission computed tomography demonstrated reduced blood flow in the cerebellum, vermis, and brainstem. After 8 weeks, his depressive state and delusion improved; however, his cenesthopathy persisted. We encountered a case of a severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3. This case supports previous studies that the cerebellum could have a role beyond motor functions.
抑郁状态是脊髓小脑性共济失调 3 型（SCA3）的常见并发症。据我们所知，尚无 SCA3 出现感觉异常的病例描述。在此，我们报告一例年轻日本男性 SCA3 患者伴感觉异常和妄想的严重抑郁状态。一位 43 岁的日本男性 SCA3 患者出现严重的抑郁状态，伴有感觉异常和妄想。他接受了艾司西酞普兰（10mg/天）和奥氮平（2.5mg/天）治疗。计算机断层扫描显示小脑、双侧小脑上脚和桥脑被盖萎缩。单光子发射计算机断层扫描显示小脑、蚓部和脑干血流减少。8 周后，他的抑郁状态和妄想改善，但感觉异常持续存在。我们遇到一例年轻日本男性 SCA3 患者伴严重抑郁状态、感觉异常和妄想。该病例支持小脑除了运动功能外可能还有其他作用的既往研究。
