Janasik Dawid, Krawczyk Tomasz
Department of Chemical Organic Technology and Petrochemistry, Silesian University of Technology, Krzywoustego, 4, 44-100, Gliwice, Poland.
Chemistry. 2022 Jan 24;28(5):e202102556. doi: 10.1002/chem.202102556. Epub 2021 Nov 24.
Magnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft-tissue contrast. This review discusses developments in the field of F MRI multimodal probes in combination with optical fluorescence imaging (OFI), H MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X-ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal F MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing F MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.
磁共振成像（MRI）是当今最强大的成像工具之一，能够显示出色的软组织对比度。本综述讨论了功能磁共振成像（fMRI）多模态探针与光学荧光成像（OFI）、氢磁共振成像（1H MRI）、化学交换饱和转移（CEST）磁共振成像、超声检查（USG）、X射线计算机断层扫描（CT）、单光子发射断层扫描（SPECT）、正电子发射断层扫描（PET）和光声成像（PAI）相结合领域的发展。在每种情况下，多模态fMRI探针都弥补了个别技术的不足，并且比单模态同类产品提供更高的检测灵敏度或准确性。文中针对fMRI多模态探针的结构、物理化学性质、生物相容性和图像质量描述了其设计策略。
