A Multiview Clustering Method With Low-Rank and Sparsity Constraints for Cancer Subtyping.

Multiomics data clustering is one of the major challenges in the field of precision medicine. Integration of multiomics data for cancer subtyping can improve the understanding on cancer and reveal systems-level insights. How to integrate multiomics data for accurate cancer subtyping is an interesting and challenging research problem. To capture the global and the local structure of omics data, a novel framework for integrating multiomics data is proposed for cancer subtyping. Multiview clustering with low-rank and sparsity constraints (MVCLRS) can measure the local similarities of samples in each omics data and obtain global consensus structures by integrating the multiomics data. The main insight provided by MVCLRS is that low-rank sparse subspace clustering for the construction of an affinity matrix can best capture the local similarities in omics data. Extensive testing is conducted on 10 real world cancer datasets with multiomics from The Cancer Genome Atlas. Compared with 10 state-of-the-art multiomics clustering algorithms, the MVCLRS performs better in the 10 cancer datasets by providing its clustering results with at least one enriched clinical label in nine of ten cancer subtypes, the most of any method.