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生物医学研究和医疗保健中类器官的创建和使用:生物伦理和代谢生物伦理问题。

Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues.

机构信息

Department of Ethics and Scientific Integrity, Foch Hospital, Suresnes, France.

Laboratory of Business Law and New Technologies (Dante) (UR4498), Paris-Saclay University (Uvsq), Montigny-Le-Bretonneux, France.

出版信息

Cell Adh Migr. 2021 Dec;15(1):285-294. doi: 10.1080/19336918.2021.1996749.

DOI:10.1080/19336918.2021.1996749
PMID:34706616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8555554/
Abstract

In the field of bioethics, scientific articles have already been published, and have highlighted relatively pluralist reflections concerning the creation and use of organoids. This plurality, rather than simply reflecting the complexity of the subject, may also be a consequence of the multiple theoretical and practical frameworks applied. Moreover, the creation and use of organoids in biomedical research and healthcare is probably in its infancy. This phenomenon is likely to increase in amplitude. Bioethics may be able to provide it with an effective and pertinent moral meaning, provided that a veritable metabioethical reflection is developed in parallel, that is, a reflection on bioethics itself, to provide scientists and clinicians with the best possible assistance in their everyday practice.

摘要

在生物伦理学领域,已经发表了一些科学文章,强调了关于类器官的创造和使用的相对多元化的思考。这种多元化并不仅仅反映了主题的复杂性,也可能是由于应用了多种理论和实践框架的结果。此外,类器官在生物医学研究和医疗保健中的创造和使用可能还处于起步阶段。这种现象可能会增加。生物伦理学可能能够为其提供有效的和恰当的道德意义,只要并行发展真正的元生物伦理学反思,即对生物伦理学本身的反思,为科学家和临床医生在日常实践中提供最好的帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00fd/8555554/58a2d1279af5/KCAM_A_1996749_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00fd/8555554/c3271fea18b4/KCAM_A_1996749_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00fd/8555554/58a2d1279af5/KCAM_A_1996749_F0002_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00fd/8555554/c3271fea18b4/KCAM_A_1996749_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00fd/8555554/58a2d1279af5/KCAM_A_1996749_F0002_B.jpg

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本文引用的文献

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Gastruloid Development Competence Discriminates Different States of Pluripotency.类囊胚发育能力可区分不同的多能状态。
Stem Cell Reports. 2021 Feb 9;16(2):354-369. doi: 10.1016/j.stemcr.2020.12.013. Epub 2021 Jan 21.
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Neural Organoids and the Precautionary Principle.神经类器官与预防原则。
医学和生物学中的良好实践:科学诚信需要全球生物伦理学。
J Transl Med. 2023 Jan 20;21(1):37. doi: 10.1186/s12967-022-03847-0.
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From a voluntary vaccination policy to mandatory vaccination against COVID-19 in cancer patients: an empirical and interdisciplinary study in bioethics.从自愿接种疫苗政策到癌症患者强制接种 COVID-19 疫苗:生物伦理学中的实证和跨学科研究。
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Scientific and Ethical Uncertainties in Brain Organoid Research.脑类器官研究中的科学与伦理不确定性
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