Daniele A, Divella R, Pilato B, Tommasi S, Pasanisi P, Patruno M, Digennaro M, Minoia C, Dellino M, Pisconti S, Casamassima P, Savino E, Paradiso A V
Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II" Bari, Viale Orazio Flacco 65, 70124, Bari, Italy.
Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori "Giovanni Paolo II" Bari, Bari, Italy.
Hered Cancer Clin Pract. 2021 Oct 27;19(1):45. doi: 10.1186/s13053-021-00199-6.
The BRCA 1 and BRCA 2 genes are associated with an inherited susceptibility to breast cancer with a cumulative risk of 60% in BRCA 1 mutation carriers and of 30% in BRCA 2 mutation carriers. Several lifestyle factors could play a role in determining an individual's risk of breast cancer. Obesity, changes in body size or unhealthy lifestyle habits such as smoking, alcohol consumption and physical inactivity have been evaluated as possible determinants of breast cancer risk. The aim of this study was to explore the current understanding of the role of harmful lifestyle and obesity or weight change in the development of breast cancer in female carriers of BRCA 1/2 mutations.
Articles were identified from MEDLINE in October 2020 utilizing related keywords; they were then read and notes, study participants, measures, data analysis and results were used to write this review.
Studies with very large case series have been carried out but only few of them have shown consistent results. Additional research would be beneficial to better determine the actual role and impact of such factors.
BRCA 1和BRCA 2基因与遗传性乳腺癌易感性相关，BRCA 1突变携带者患乳腺癌的累积风险为60%，BRCA 2突变携带者为30%。多种生活方式因素可能在决定个体患乳腺癌风险中发挥作用。肥胖、体型变化或不健康的生活习惯，如吸烟、饮酒和缺乏体育锻炼，已被评估为乳腺癌风险的可能决定因素。本研究的目的是探讨目前对有害生活方式、肥胖或体重变化在BRCA 1/2突变女性携带者患乳腺癌过程中所起作用的理解。
2020年10月从MEDLINE中利用相关关键词检索文章；然后阅读这些文章，并根据研究参与者、测量方法、数据分析和结果撰写本综述。
已经开展了一些有非常大病例系列的研究，但其中只有少数研究显示出一致的结果。进一步的研究将有助于更好地确定这些因素的实际作用和影响。
