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阿尔茨海默病发病预测与预防模型。

A Predictive and Preventive Model for Onset of Alzheimer's Disease.

机构信息

School of Computer Science and Engineering, Vellore Institute of Technology, Vellore, India.

School of Information Technology and Engineering, Vellore Institute of Technology, Vellore, India.

出版信息

Front Public Health. 2021 Oct 11;9:751536. doi: 10.3389/fpubh.2021.751536. eCollection 2021.

Abstract

Alzheimer's Disease (AD) is a neurodegenerative irreversible brain disorder that gradually wipes out the memory, thinking skills and eventually the ability to carry out day-to-day tasks. The amount of AD patients is rapidly increasing due to several lifestyle changes that affect biological functions. Detection of AD at its early stages helps in the treatment of patients. In this paper, a predictive and preventive model that uses biomarkers such as the amyloid-beta protein is proposed to detect, predict, and prevent AD onset. A Convolution Neural Network (CNN) based model is developed to predict AD at its early stages. The results obtained proved that the proposed model outperforms the traditional Machine Learning (ML) algorithms such as Logistic Regression, Support Vector Machine, Decision Tree Classifier, and K Nearest Neighbor algorithms.

摘要

阿尔茨海默病(AD)是一种神经退行性不可逆的脑部疾病,会逐渐抹去记忆、思维能力,最终丧失日常任务的执行能力。由于影响生物功能的几种生活方式的改变,AD 患者的数量正在迅速增加。在早期发现 AD 有助于对患者进行治疗。在本文中,提出了一种使用淀粉样蛋白-β等生物标志物的预测和预防模型,以检测、预测和预防 AD 的发病。开发了一种基于卷积神经网络(CNN)的模型来早期预测 AD。结果证明,所提出的模型优于传统的机器学习(ML)算法,如逻辑回归、支持向量机、决策树分类器和 K 最近邻算法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/8542726/7e756c3ba854/fpubh-09-751536-g0001.jpg

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