Pryimak Nazar, Zaiachuk Mariia, Kovalchuk Olga, Kovalchuk Igor
Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada.
Front Cell Dev Biol. 2021 Oct 11;9:715380. doi: 10.3389/fcell.2021.715380. eCollection 2021.
Fibrosis is a condition characterized by thickening or/and scarring of various tissues. Fibrosis may develop in almost all tissues and organs, and it may be one of the leading causes of morbidity and mortality. It provokes excessive scarring that excels the usual wound healing response to trauma in numerous organs. Currently, very little can be done to prevent tissue fibrosis, and it is almost impossible to reverse it. Anti-inflammatory and immunosuppressive drugs are among the few treatments that may be efficient in preventing fibrosis. Numerous publications suggest that cannabinoids and extracts of have potent anti-inflammatory and anti-fibrogenic properties. In this review, we describe the types and mechanisms of fibrosis in various tissues and discuss various strategies for prevention and dealing with tissue fibrosis. We further introduce cannabinoids and their potential for the prevention and treatment of fibrosis, and therefore for extending healthy lifespan.
纤维化是一种以各种组织增厚或/和瘢痕形成为特征的病症。纤维化几乎可在所有组织和器官中发生，并且可能是发病和死亡的主要原因之一。它会引发过度瘢痕形成，在许多器官中超过了对创伤的正常伤口愈合反应。目前，几乎无法预防组织纤维化，而且几乎不可能逆转它。抗炎和免疫抑制药物是少数可能有效预防纤维化的治疗方法。众多出版物表明，大麻素及其提取物具有强大的抗炎和抗纤维化特性。在本综述中，我们描述了各种组织中纤维化的类型和机制，并讨论了预防和处理组织纤维化的各种策略。我们进一步介绍了大麻素及其预防和治疗纤维化的潜力，从而延长健康寿命。
