基于 miRNA 触发的纳米酶级联反应的肿瘤特异性化学动力学治疗。
MicroRNA-Triggered Nanozymes Cascade Reaction for Tumor-Specific Chemodynamic Therapy.
机构信息
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
出版信息
Chemistry. 2021 Dec 23;27(72):18201-18207. doi: 10.1002/chem.202103547. Epub 2021 Nov 16.
Off-target toxicity and insufficient hydroxyl radicals ( OH) generation limit the further clinical application of nanozymes in chemodynamic therapy (CDT). Herein, we designed and constructed a microRNA-triggered nanozyme cascade platform for enhanced tumor-specific chemodynamic therapy. The nanozyme-based cascade reaction could be triggered successfully by the high expression of microRNA in cancer cells to generate more OH, thus exhibiting excellent tumor-specific therapeutic performance. Our work provides a new dimension for tumor-specific chemodynamic therapy.
脱靶毒性和羟基自由基（OH）生成不足限制了纳米酶在化学动力学治疗（CDT）中的进一步临床应用。在此，我们设计并构建了一种 microRNA 触发的纳米酶级联平台，用于增强肿瘤特异性化学动力学治疗。基于纳米酶的级联反应可以通过癌细胞中 microRNA 的高表达被成功触发，从而产生更多的 OH，从而表现出优异的肿瘤特异性治疗性能。我们的工作为肿瘤特异性化学动力学治疗提供了一个新的维度。
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