Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110016, China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
J Asian Nat Prod Res. 2021 Nov;23(11):1043-1050. doi: 10.1080/10286020.2021.1993835. Epub 2021 Oct 28.
Two new prenylated coumarins, 3'-hydroxytoddanone (), and isotoddalolactone (), along with four known analogues (-) were isolated from the roots of . Their chemical structures were elucidated based on extensive spectroscopic interpretation and HR-ESI-MS analysis. The absolute configuration of compound was determined by comparing experimental ECD spectrum with that calculated by the time-dependent density functional theory (TDDFT) method. Compounds were isolated from the genus for the first time. The two new compounds were tested for antiproliferative activities on the HL-60, K562 and THP-1 cell lines. Compounds and exhibited moderate cell growth inhibitory activities against human leukemic HL-60 cell lines, with IC values of 32.64 and 33.15 µM, respectively.
从 的根部分离得到了两个新的prenylated coumarins，3'-hydroxytoddanone () 和 isotoddalolactone ()，以及四个已知的类似物 (-)。基于广泛的光谱解释和 HR-ESI-MS 分析，确定了它们的化学结构。通过将实验 ECD 光谱与通过时间相关密度泛函理论 (TDDFT) 方法计算的光谱进行比较，确定了化合物 的绝对构型。化合物 是首次从 属中分离得到的。对这两个新化合物进行了抗增殖活性测试，结果表明它们对 HL-60、K562 和 THP-1 细胞系具有中等的细胞生长抑制活性。化合物 和 对人白血病 HL-60 细胞系的细胞生长抑制活性分别为 32.64 和 33.15 μM。
