Schmidt D N
Scand J Gastroenterol Suppl. 1986;126:69-74. doi: 10.3109/00365528609091897.
Previous studies had shown an atropine sensitive, excitatory action of i.v. ethanol on pancreatic protein secretion in alcohol fed dogs and also an increased intrapancreatic acetylcholine activity. In an attempt to clarify these observations, the dose-inhibition effect of atropine, the dose-response effect of a cholinergic agonist and the effect of vagal stimulation on pancreatic protein output in alcoholic and normal dogs was compared. The inhibitory effect of atropine and the effect of vagal stimulation were unchanged but the sensitivity to exogenous cholinergic stimulation was decreased in alcoholic dogs compared to normals. It is suggested, that the chronic repetitive ethanol exposure of acinar muscarinic receptors, desensitizes them to cholinergic stimulation but induces paradoxical sensitivity to ethanol, while the interaction of atropine is left unchanged. The increased availability of acetylcholine would only be an adaptive phenomenon to the desensitization.
先前的研究表明，静脉注射乙醇对喂食酒精的犬胰腺蛋白质分泌具有阿托品敏感的兴奋作用，并且胰腺内乙酰胆碱活性增加。为了阐明这些观察结果，比较了阿托品的剂量抑制作用、胆碱能激动剂的剂量反应效应以及迷走神经刺激对酒精性犬和正常犬胰腺蛋白质输出的影响。与正常犬相比，酒精性犬中阿托品的抑制作用和迷走神经刺激的作用未发生变化，但对外源性胆碱能刺激的敏感性降低。有人提出，腺泡毒蕈碱受体长期反复暴露于乙醇会使其对胆碱能刺激脱敏，但会诱导对乙醇的反常敏感性，而阿托品的相互作用则保持不变。乙酰胆碱可用性的增加只是对脱敏的一种适应性现象。
