Alonso R M, Alvarez M C, San Román J I, García L J, Calvo J J, López M A
Deparatamento de Fisiología y Farmacología Universidad de Salamanca, Salamanca, Spain.
Rev Esp Fisiol. 1994 Jun;50(2):81-7.
The effect of intravenous infusion of ethanol on the basal exocrine pancreatic secretion of anesthetized rats was studied. The cholinergic involvement on the actions of ethanol was also studied using previously atropinized animals. During the stimulation period, pancreatic flow rate was significantly increased by intravenous ethanol in both un-atropinized (199% compared with basal) and atropinized rats (195% compared with basal). Pancreatic protein output was also increased during ethanol administration in both groups of animals (171% and 165% compared with basal in, respectively, un-atropinized and atropinized rats). After the administration of ethanol, in the poststimulation period, pancreatic flow rate was further increased only in the atropinized group of rats (290% compared with basal), whose values were significantly higher than those of ethanol-treated un-atropinized animals (195% compared with basal). A similar profile of response was observed in pancreatic protein output. Since intravenous ethanol did not stimulate either secretin or VIP release to portal plasma, the present results point to a direct effect of this substance on the exocrine pancreas. Furthermore, atropine revealed the existence of an inhibitory cholinergic effect of ethanol on the exocrine pancreas. In summary, results show that the effect of intravenous ethanol on the basal exocrine pancreatic secretion is dual and antagonistic.
研究了静脉输注乙醇对麻醉大鼠基础胰腺外分泌的影响。还使用先前已用阿托品处理的动物研究了胆碱能对乙醇作用的影响。在刺激期，未用阿托品处理的大鼠（与基础值相比增加199%）和用阿托品处理的大鼠（与基础值相比增加195%）静脉注射乙醇后胰腺流速均显著增加。两组动物在给予乙醇期间胰腺蛋白输出也增加（未用阿托品处理和用阿托品处理的大鼠分别与基础值相比为171%和165%）。给予乙醇后，在刺激后时期，仅在用阿托品处理的大鼠组中胰腺流速进一步增加（与基础值相比为290%），其值显著高于乙醇处理的未用阿托品处理的动物（与基础值相比为195%）。胰腺蛋白输出也观察到类似的反应模式。由于静脉注射乙醇未刺激促胰液素或血管活性肠肽释放至门静脉血浆，目前的结果表明该物质对胰腺外分泌有直接作用。此外，阿托品揭示了乙醇对外分泌胰腺存在抑制性胆碱能作用。总之，结果表明静脉注射乙醇对基础胰腺外分泌的作用是双重且拮抗的。
