College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
Chem Commun (Camb). 2021 Nov 11;57(90):12000-12003. doi: 10.1039/d1cc03835d.
Three perylene bisimide-glycopeptide conjugates (PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal) were synthesized, which showed moderate activity in the control of ice crystal growth. Furthermore, the cellular cryopreservation effects of PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal showed enhancements in cell viabilities, especially for PBI-AFF-Glu with values of 22.77 ± 3.33% (HeLa cells), 19.43 ± 1.90% (A549 cells) and 16.63 ± 1.76% (GES-1 cells) at a dose of 1.0 mg mL. This work will help guide the development of self-assembled cryoprotectants.
三种苝二酰亚胺-糖肽缀合物（PBI-AFF-Man、PBI-AFF-Glu 和 PBI-AFF-Gal）被合成，它们在控制冰晶生长方面表现出中等活性。此外，PBI-AFF-Man、PBI-AFF-Glu 和 PBI-AFF-Gal 的细胞冷冻保存效果增强了细胞活力，特别是对于 PBI-AFF-Glu，在剂量为 1.0 mg/mL 时，其值分别为 22.77±3.33%（HeLa 细胞）、19.43±1.90%（A549 细胞）和 16.63±1.76%（GES-1 细胞）。这项工作将有助于指导自组装冷冻保护剂的开发。
