Safarzadeh Saba, Shirban Farinaz, Bagherniya Mohammad, Sathyapalan Thozhukat, Sahebkar Amirhossein
Post Graduate Student, Dental Students' Research Committee, Department of Orthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Orthodontics, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Phytother Res. 2022 Jan;36(1):243-265. doi: 10.1002/ptr.7308. Epub 2021 Oct 28.
Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free radicals can act as a trigger for an inflammatory milieu that causes OM. Based on the debilitating nature of OM, finding a safe and inexpensive agent with anti-inflammatory, anti-microbial, and antioxidative properties can be valuable for this situation. Considering the harmful effects of some chemical agents, herbal medicine has been suggested as a potential alternative owing to unique properties such as safety, availability and low cost. Many studies have illustrated several pharmacological properties of herbal medicines in recent years, such as anti-inflammatory, anti-microbial, and antioxidative activities, which are essential factors in the palliation of cancer therapy-induced OM. This review aimed to evaluate herbal medicines' effects on cancer therapy-induced OM. According to this comprehensive review, it is concluded that medicinal plants and phytochemicals can be used as practical agents in the palliation of cancer therapy-induced OM without any serious side effects.
癌症治疗引起的口腔黏膜炎（OM）是放化疗后最棘手的并发症之一。年龄、营养状况、肿瘤类型、口腔卫生和治疗方法是OM发生率的决定因素。此外，氧自由基可引发导致OM的炎症环境。鉴于OM的致残性，找到一种具有抗炎、抗菌和抗氧化特性的安全且廉价的药物对这种情况可能很有价值。考虑到一些化学药物的有害影响，由于草药具有安全、易得和低成本等独特特性，已被建议作为一种潜在的替代药物。近年来，许多研究阐述了草药的几种药理特性，如抗炎、抗菌和抗氧化活性，这些是缓解癌症治疗引起的OM的关键因素。本综述旨在评估草药对癌症治疗引起的OM的影响。根据这一全面综述，得出的结论是药用植物和植物化学物质可作为缓解癌症治疗引起的OM的实用药物，且无任何严重副作用。
