Institute of Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Str, University Medicine Greifswald, D-17475, Greifswald, Germany.
Internal Medicine C, Ferdinand-Sauerbruch-Str, University Medicine Greifswald, D-17475, Greifswald, Germany.
BMC Oral Health. 2023 Mar 26;23(1):176. doi: 10.1186/s12903-023-02884-5.
Oral mucositis caused by intensive cancer chemotherapy or radiotherapy frequently results in pronounced damage of the oral mucosa leading to painful oral hygiene. To support oral care, antimicrobial effective mouth rinses may be used. Thus, the efficacy of a hypochlorite-based mouth rinse (Granudacyn®), assumed to be highly biocompatible because of the compounds being part of the natural pathogen defense, as possible antiseptic agent in case of oral mucositis was compared to that of an octenidine based antiseptic mouth rinse (Octenidol® md).
The study was conducted as monocentric, controlled, randomized, blind cross over comparative study on 20 volunteers. As a proof of principle, we performed the study on orally healthy subjects and not cancer patients. The efficacy was determined as reduction of colony forming units (cfu) on buccal mucosa as well as in saliva. After mouth rinsing for 30 s, samples were taken after 1 min, 15 min, 30 and 60 min. The lg-reduction was calculated as difference between lg-values of cfu pre- and post-treatment.
Both antiseptic mouth rinses induced a significant reduction of cfu on buccal mucosa and in saliva 1 min after mouth rinsing. The effect persisted up to 60 min. The octenidine based rinse was significantly superior to the hypochlorite-based rinse up to the last sample 60 min after rinsing. However, the known cytotoxicity of octenidine argues against its application.
Within the limits of this study, due to its antiseptic efficacy, the hypochlorite-based rinse Granudacyn® can be regarded appropriate to support the oral hygiene in patients with a sensitive oral mucosa during an aggressive cancer chemotherapy and radiation treatment in case of oral mucositis.
由强化癌症化疗或放疗引起的口腔粘膜炎常导致口腔粘膜明显损伤，导致口腔卫生疼痛。为了支持口腔护理，可以使用具有抗菌作用的漱口液。因此，比较了一种基于次氯酸盐的漱口液（Granudacyn®）和一种基于奥替尼啶的抗菌漱口液（Octenidol® md）的疗效，前者被认为由于化合物是天然病原体防御的一部分，因此具有高度的生物相容性，作为口腔粘膜炎的可能防腐剂。
该研究是在 20 名志愿者中进行的单中心、对照、随机、双盲交叉比较研究。作为原理验证，我们在口腔健康受试者而非癌症患者中进行了这项研究。疗效通过颊粘膜和唾液中的菌落形成单位（cfu）减少来确定。漱口 30 秒后，在 1 分钟、15 分钟、30 分钟和 60 分钟后取样。lg 减少量计算为治疗前后 cfu lg 值的差异。
两种抗菌漱口液在漱口后 1 分钟均可显著减少颊粘膜和唾液中的 cfu。这种效果持续到 60 分钟。奥替尼啶漱口液的效果明显优于次氯酸盐漱口液，直至最后一次漱口后 60 分钟。然而，奥替尼啶的已知细胞毒性反对其应用。
在本研究范围内，由于其抗菌功效，基于次氯酸盐的漱口液 Granudacyn®可被认为适合在接受强化癌症化疗和放疗的敏感口腔粘膜患者中支持口腔卫生，以防口腔粘膜炎。
