Anatomical knowledge based level set segmentation of cardiac ventricles from MRI.

This paper represents a novel level set framework for segmentation of cardiac left ventricle (LV) and right ventricle (RV) from magnetic resonance images based on anatomical structures of the heart. We first propose a level set approach to recover the endocardium and epicardium of LV by using a bi-layer level set (BILLS) formulation, in which the endocardium and epicardium are represented by the 0-level set and k-level set of a level set function. Furthermore, the recovery of LV endocardium and epicardium is achieved by a level set evolution process, called convexity preserving bi-layer level set (CP-BILLS). During the CP-BILLS evolution, the 0-level set and k-level set simultaneously evolve and move toward the true endocardium and epicardium under the guidance of image information and the impact of the convexity preserving mechanism as well. To eliminate the manual selection of the k-level, we develop an algorithm for automatic selection of an optimal k-level. As a result, the obtained endocardial and epicardial contours are convex and consistent with the anatomy of cardiac ventricles. For segmentation of the whole ventricle, we extend this method to the segmentation of RV and myocardium of both left and right ventricles by using a convex shape decomposition (CSD) structure of cardiac ventricles based on anatomical knowledge. Experimental results demonstrate promising performance of our method. Compared with some traditional methods, our method exhibits superior performance in terms of segmentation accuracy and algorithm stability. Our method is comparable with the state-of-the-art deep learning-based method in terms of segmentation accuracy and algorithm stability, but our method has no need for training and the manual segmentation of the training data.