Sheng Yunjiao, Qiu Hong, Chen Sijuan
Department of Health Care, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan 250012, Shandong Province, China.
Central Pharmacy, Qingdao Municipal Hospital, Qingdao 266000, Shandong Province, China.
Evid Based Complement Alternat Med. 2021 Oct 19;2021:7297361. doi: 10.1155/2021/7297361. eCollection 2021.
The purpose was to explore the clinical effect of Danqi Buxin decoction on chronic heart failure (CHF) with yang deficiency and its effect on cardiac function and life quality of patients.
106 CHF patients with yang deficiency treated in Jinan Municipal Hospital of Traditional Chinese Medicine from February 2019 to February 2020 were selected as the research objects and divided into the treatment group and reference group according to the odd and even admission numbers, with 53 cases in each group. The reference group was treated with routine antiheart failure drugs, while the treatment group was additionally treated with Danqi Buxin decoction to compare the clinical effect and cardiac function changes between the two groups.
The clinical effective rate in the treatment group was significantly higher than that in the reference group ( < 0.05). The TCM symptom scores at T1, T2, and T3 in the treatment group were significantly higher than those in the reference group ( < 0.05). After treatment, the LVEDV levels in both groups were significantly higher than those before treatment, while the BNP levels were significantly lower than those before treatment ( < 0.001). The LVEDV level in the treatment group after treatment was higher than that in the reference group, while the BNP level in the treatment group was significantly lower than that in the reference group ( < 0.001). The life quality scores in the treatment group after treatment were significantly higher than those in the reference group ( < 0.05).
Danqi Buxin decoction on the basis of conventional drugs can significantly improve the cardiac function and life quality of CHF patients with yang deficiency type. Its further research is helpful to establish a good treatment plan for CHF patients.
探讨丹芪补心汤治疗阳虚型慢性心力衰竭（CHF）的临床疗效及其对患者心功能和生活质量的影响。
选取2019年2月至2020年2月在济南市中医医院治疗的106例阳虚型CHF患者作为研究对象，按照入院序号奇偶分为治疗组和参照组，每组53例。参照组采用常规抗心力衰竭药物治疗，治疗组在常规治疗基础上加用丹芪补心汤，比较两组临床疗效及心功能变化。
治疗组临床有效率显著高于参照组（<0.05）。治疗组T1、T2、T3时中医症状评分显著高于参照组（<0.05）。治疗后，两组左心室舒张末期容积（LVEDV）水平均显著高于治疗前，而脑钠肽（BNP）水平均显著低于治疗前（<0.001）。治疗后治疗组LVEDV水平高于参照组，而治疗组BNP水平显著低于参照组（<0.001）。治疗后治疗组生活质量评分显著高于参照组（<0.05）。
在常规药物基础上加用丹芪补心汤可显著改善阳虚型CHF患者的心功能和生活质量。对其进一步研究有助于为CHF患者制定良好的治疗方案。
