Niknam Ramin, Salehi Alireza, Molavi Vardanjani Hossein, Fattahi Mohammad Reza, Dehghani Seyed-Mohsen, Honar Nasser, Haghighat Mahmood, Imanieh Mohammad-Hadi
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
MPH Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Middle East J Dig Dis. 2021 Apr;13(2):121-130. doi: 10.34172/mejdd.2021.215. Epub 2021 May 29.
BACKGROUND Celiac disease is a common disorder but there are few studies comparing the clinical features of the disease in adults, adolescents and children. METHODS Demographic and clinical characteristics of all patients with celiac disease referred to the Celiac Clinic were evaluated and compared in different age groups. RESULTS Of 3416 participants, 473 patients were included. 302 (63.8%) were women and 171 (36.2%) were men. Overall, 325 (68.7%) and 411 (86.9%) patients had gastrointestinal (GI) and non-GI manifestations, respectively. The most common symptom in adults was psychiatric problems (66.5%), while abdominal discomfort was the most common symptom in adolescents (45.2%) and children (53.8%). According to age groups, GI manifestations were seen in 79 (66.4%), 119 (59.8%), and 127 (81.9%) children, adolescents, and adults, respectively. Adults had significantly more GI manifestations than the other groups (PR 1.167; 95% CI: 1.094- 1.244; < 0.001). Non-GI manifestations were seen in 90 (75.6%), 174 (87.4%), and 147 (94.8%) children, adolescents, and adults, respectively. Adults had significantly more non-GI manifestations than the other groups (PR 1.112; 95% CI: 1.060-1.168; < 0.001). CONCLUSION Our study showed that there were significant differences in the clinical features of celiac disease between the different age groups. Considering these results may help plan for future studies.
乳糜泻是一种常见疾病，但比较成人、青少年和儿童该疾病临床特征的研究较少。方法：对转诊至乳糜泻诊所的所有乳糜泻患者的人口统计学和临床特征进行评估，并在不同年龄组之间进行比较。结果：在3416名参与者中，纳入了473例患者。其中302例（63.8%）为女性，171例（36.2%）为男性。总体而言，分别有325例（68.7%）和411例（86.9%）患者有胃肠道（GI）和非胃肠道表现。成人中最常见的症状是精神问题（66.5%），而腹部不适是青少年（45.2%）和儿童（53.8%）中最常见的症状。按年龄组划分，儿童、青少年和成人中分别有79例（66.4%）、119例（59.8%）和127例（81.9%）出现胃肠道表现。成人的胃肠道表现明显多于其他组（PR 1.167；95%CI：1.094 - 1.244；<0.001）。儿童、青少年和成人中分别有90例（75.6%）、174例（87.4%）和147例（94.8%）出现非胃肠道表现。成人的非胃肠道表现明显多于其他组（PR 1.112；95%CI：1.060 - 1.168；<0.001）。结论：我们的研究表明，不同年龄组乳糜泻的临床特征存在显著差异。考虑这些结果可能有助于未来研究的规划。
