Department of Radiology, Hangzhou Children's Hospital, Hangzhou, Zhejiang 310014, China.
Department of Radiology, Yin Zhou Second Hospital, Ningbo, Zhejiang 315040, China.
J Healthc Eng. 2021 Oct 19;2021:2800891. doi: 10.1155/2021/2800891. eCollection 2021.
The pathological changes of myocarditis include degeneration and necrosis of myocardial cells and infiltration of inflammatory cells in the myocardial interstitium, accompanied by obvious myocardial fibrosis. Myocardial fibrosis is a determinant of ventricular remodeling and an important indicator of the classification of clinical risk factors and has an important value in evaluating the prognosis of heart disease. Cardiac magnetic resonance (CMR) is the "gold standard" for evaluating the shape and function of the heart, and it can show the characteristic pathological changes of myocardial tissue. The traditional gadolinium imaging agent delays the enhanced sequence images to visually show the extent of the affected myocardial fibrosis, but it cannot effectively identify small focal fibrosis or widespread diffuse fibrosis. The CMR longitudinal relaxation time quantitative technique can directly measure the relaxation time (T1) determined by the myocardial tissue and does not depend on the signal strength of the reference tissue and can quantitatively analyze the affected myocardium. In this study, the initial and enhanced quantitative imaging techniques of CMR were used to measure the magnetic value of the myocardium in patients with myocarditis, to explore the diagnostic value of myocardial fibrosis, and to analyze the correlation between cardiac fibrosis and cardiac function.
心肌炎的病理学变化包括心肌细胞的变性和坏死以及心肌间质中炎性细胞的浸润，并伴有明显的心肌纤维化。心肌纤维化是心室重构的决定因素，也是临床危险因素分类的重要指标，对评估心脏病的预后具有重要价值。心脏磁共振（CMR）是评估心脏形态和功能的“金标准”，可以显示心肌组织的特征性病理变化。传统的钆造影剂延迟增强序列图像可直观显示受影响心肌纤维化的程度，但无法有效识别小灶性纤维化或广泛弥漫性纤维化。CMR 纵向弛豫时间定量技术可直接测量心肌组织确定的弛豫时间（T1），不依赖于参照组织的信号强度，并可对受累心肌进行定量分析。在这项研究中，使用 CMR 的初始和增强定量成像技术来测量心肌炎患者的心肌磁值，以探讨心肌纤维化的诊断价值，并分析心脏纤维化与心功能之间的相关性。
