Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China.
Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China.
Int J Mol Med. 2022 Jan;49(1). doi: 10.3892/ijmm.2021.5056. Epub 2021 Oct 29.
Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress has been made in recent years, CRC survival remains unsatisfactory due to high metastasis and recurrence. Understanding the underlying molecular mechanisms of CRC tumorigenesis and metastasis has become increasingly important. Recently, aberrant Wnt/β‑catenin signaling has been reported to be strongly associated with CRC tumorigenesis, metastasis and recurrence. Therefore, the Wnt/β‑catenin signaling pathway has potential value as a therapeutic target for CRC. In the present review, the dysregulation of this pathway in CRC and the promoting or suppressing function of therapeutic targets on CRC were explored. In addition, the interaction between this pathway and epithelial‑mesenchymal transition (EMT), cell stemness, mutations, metastasis‑related genes and tumor angiogenesis in CRC cells were also investigated. Numerous studies on this pathway may help identify the potential diagnostic and prognostic markers and therapeutic targets for CRC.
结直肠癌（CRC）是最常见的癌种之一。尽管近年来取得了重大进展，但由于高转移和复发，CRC 的生存率仍不理想。了解 CRC 发生和转移的潜在分子机制变得越来越重要。最近有报道称，异常的 Wnt/β-catenin 信号与 CRC 的发生、转移和复发密切相关。因此，Wnt/β-catenin 信号通路具有作为 CRC 治疗靶点的潜在价值。在本综述中，探讨了该通路在 CRC 中的失调以及治疗靶点对 CRC 的促进或抑制作用。此外，还研究了该通路与 CRC 细胞中的上皮-间充质转化（EMT）、细胞干性、突变、转移相关基因和肿瘤血管生成之间的相互作用。对该通路的大量研究可能有助于确定 CRC 的潜在诊断和预后标志物以及治疗靶点。
