Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tuebingen, Tuebingen, Germany.
Centre of Excellence for Eating Disorders (KOMET), University of Tuebingen, Tuebingen, Germany.
Eur Eat Disord Rev. 2022 Jan;30(1):75-81. doi: 10.1002/erv.2870. Epub 2021 Oct 28.
Maternal eating disorders (EDs) are associated with adverse pregnancy and child outcomes. There is limited research investigating the influence of maternal EDs on foetal brain development.
Using foetal magnetoencephalography (fMEG), an auditory sequence was presented for 10 min to assess brain response latencies in foetuses of mothers with (n = 12) and without (n = 11) a history of anorexia nervosa (AN) in the third trimester of pregnancy. ED history and severity were assessed using the structured clinical expert interview eating disorder examination (EDE) and the self-report questionnaire EDE-Q.
Foetuses of mothers with AN showed delayed foetal brain responses to auditory stimulation compared to foetuses of control women. Self-reported ED symptom severity explained 34% of variance in foetal brain response latencies in the AN group.
ED pathology was strongly associated with foetal brain response latencies in the third trimester with longer latencies in foetuses of women with a history of AN reporting more ED symptoms. Follow-up on the children is pivotal to investigate if fMEG outcomes are associated with later child development.
母体进食障碍（ED）与不良妊娠和儿童结局有关。目前，关于母体 ED 对胎儿大脑发育影响的研究有限。
使用胎儿脑磁图（fMEG），对妊娠晚期患有（n=12）和未患有（n=11）神经性厌食症（AN）的母亲的胎儿进行 10 分钟的听觉序列，以评估大脑反应潜伏期。使用结构化临床专家访谈进食障碍检查（EDE）和自我报告问卷 EDE-Q 评估 ED 病史和严重程度。
与对照组女性相比，患有 AN 的母亲的胎儿对听觉刺激的胎儿大脑反应延迟。自我报告的 ED 症状严重程度解释了 AN 组胎儿大脑反应潜伏期变异性的 34%。
ED 病理与妊娠晚期胎儿大脑反应潜伏期密切相关，有 AN 病史且报告 ED 症状较多的女性的胎儿潜伏期较长。对儿童进行随访对于调查 fMEG 结果是否与后期儿童发育有关至关重要。
