水相和可见光促进的尿嘧啶衍生物与重氮盐的C-H（杂）芳基化反应
Aqueous and Visible-Light-Promoted C-H (Hetero)arylation of Uracil Derivatives with Diazoniums.
作者信息
Liu An-Di, Wang Zhao-Li, Liu Li, Cheng Liang
机构信息
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
J Org Chem. 2021 Dec 3;86(23):16434-16447. doi: 10.1021/acs.joc.1c01799. Epub 2021 Oct 29.
Direct C5 (hetero)arylation of uracil and uridine substrates with (hetero)aryl diazonium salts under photoredox catalysis with blue light was reported. The coupling proceeds efficiently with diazonium salts and heterocycles in good functional group tolerance at room temperature in aqueous solution without transition-metal components. A plausible radical mechanism has been proposed.
报道了在蓝光光氧化还原催化下，尿嘧啶和尿苷底物与（杂）芳基重氮盐的直接C5（杂）芳基化反应。该偶联反应在室温下于水溶液中，在无过渡金属成分的情况下，能与重氮盐和杂环高效进行，且官能团耐受性良好。已提出了一种合理的自由基机理。
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