Mallinckrodt Institute of Radiology, 12275Washington University in St Louis, St Louis, MO, USA.
Department of Medical Oncology, 22916Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Acta Radiol. 2022 Sep;63(9):1166-1172. doi: 10.1177/02841851211054193. Epub 2021 Oct 29.
Myocardial uptake on Ga-DOTATATE PET/CT is often observed and its clinical relevance is poorly understood.
To detect any correlation between myocardial uptake of Ga-DOTATATE and presence of cardiac disease or risk factors.
In this institutional review board-approved retrospective study, we reviewed Ga-DOTATATE PET/CT scans in our institution between 1 May 2018 and 30 September 2018. A semi-quantitative score (MUS) for myocardial uptake of Ga-DOTATATE was developed by measuring mean standardized uptake value (SUV) in five myocardial regions, corrected by blood pool activity, and MUS was validated between two readers. We investigated the relationship between MUS and presence of cardiac disease or risk factors, including Framingham score and coronary calcification.
A total of 145 scans were included (79 women; mean age = 56.9 ± 13.7 years). Inter-reader agreement was excellent with intraclass correlation coefficient (r) = 0.964 (95% confidence interval [CI] = 0.903-0.987; < 0.001). There was a weak but significant positive correlation between MUS and presence of coronary calcifications (Spearman rho = 0.20; = 0.016). MUS was higher in patients with heart disease or risk factors (n = 83, mean MUS 2.03, 95% CI = 1.85-2.21) compared to those without (n = 23, mean MUS 1.40, 95% CI = 1.17-1.62; < 0.001), although the cardiac disease group was older with a higher percentage of men (62.0 years, 57.8% men compared to 47.6 years, 13.0% men; value <0.0001 for both comparisons).
For patients undergoing Ga-DOTATATE PET/CT scan, an elevated MUS might indicate an underlying heart disease.
Ga-DOTATATE PET/CT 常观察到心肌摄取，但其临床相关性尚不清楚。
检测 Ga-DOTATATE 心肌摄取与心脏疾病或危险因素之间的任何相关性。
在这项机构审查委员会批准的回顾性研究中，我们回顾了我院在 2018 年 5 月 1 日至 2018 年 9 月 30 日之间进行的 Ga-DOTATATE PET/CT 扫描。通过测量五个心肌区域的平均标准化摄取值（SUV），并校正血池活性，开发了 Ga-DOTATATE 心肌摄取的半定量评分（MUS），并由两位读者验证。我们研究了 MUS 与心脏疾病或危险因素（包括 Framingham 评分和冠状动脉钙化）之间的关系。
共纳入 145 例扫描（79 例女性；平均年龄 56.9 ± 13.7 岁）。两位读者之间的一致性极好，组内相关系数（r）为 0.964（95%置信区间[CI] = 0.903-0.987； < 0.001）。MUS 与冠状动脉钙化的存在呈弱但有统计学意义的正相关（Spearman rho = 0.20； = 0.016）。患有心脏疾病或危险因素的患者（n = 83，MUS 平均值 2.03，95% CI = 1.85-2.21）的 MUS 高于无心脏疾病或危险因素的患者（n = 23，MUS 平均值 1.40，95% CI = 1.17-1.62； < 0.001），尽管心脏疾病组年龄较大，男性比例较高（62.0 岁，57.8%男性与 47.6 岁，13.0%男性；两者的比较均 value <0.0001）。
对于接受 Ga-DOTATATE PET/CT 扫描的患者，升高的 MUS 可能表明存在潜在的心脏疾病。
