Yale New Haven Health - Bridgeport Hospital, Bridgeport, Connecticut.
University of Kentucky College of Medicine, Department of Internal Medicine, Division of Cancer Biostatistics, Lexington, Kentucky; University of Kentucky College of Medicine, Markey Cancer Center, Biostatistics and Bioinformatics Shared Resource Facility, Lexington, Kentucky.
Acad Radiol. 2022 Jan;29(1):95-106. doi: 10.1016/j.acra.2020.08.028. Epub 2020 Oct 21.
Standardized Uptake Value (SUV) is an important semiquantitative measurement used in the clinical and research domains to assess radiopharmaceutical concentration in tumors versus normal organs, but is susceptible to many factors beyond the tumor biological environment. So, the aim of this study is to identify the optimum internal reference among organs with physiological uptake in Ga-DOTATATE PET/CT (DOTA PET/CT) scans.
This HIPAA-compliant, IRB-approved study with waiver of consent included retrospective imaging review of 180 consecutive patients with neuroendocrine tumors presenting for DOTA PET/CT image acquisition: Ga- DOTATATE dose was reported as (0.054 mCi/Kg) scans between September 2018 and May 2019. Mean value of body weight normalized SUV (SUV) and lean body mass normalized SUV (SUL) of liver and spleen were measured. Information about the patients and scan characteristics were collected. The paired Grambsch test was used to compare variance among the measured SUVs. Spearman's rank correlation coefficient was used to assess correlation between SUVs and potential patient- and scan-specific confounding factors.
Variance of SUL was significantly lower than variance of SUV in both liver and spleen (p-value < 0.0001). Variances of liver SUV and SUL were significantly lower than the corresponding spleen SUVs. Liver SUL showed the lowest variance (3.69% ± 1.25%) among all measured SUVs.
SUL is a more reproducible, less variable, and therefore more reliable quantitative measure in DOTA PET/CT scans, compared SUV. Among the available organs with physiological uptake, liver SUL is the optimum internal reference given the liver's larger size and uniform SUL values resulting in lower variability and better reproducibility.
标准化摄取值（SUV）是一种在临床和研究领域中用于评估肿瘤与正常器官之间放射性药物浓度的重要半定量测量方法，但它容易受到肿瘤生物学环境以外的许多因素的影响。因此，本研究的目的是确定 Ga-DOTATATE PET/CT（DOTA PET/CT）扫描中具有生理摄取的器官中最佳的内参。
这项符合 HIPAA 标准、IRB 批准的研究豁免了同意书，回顾性地分析了 180 名连续的神经内分泌肿瘤患者的 DOTA PET/CT 图像：Ga-DOTATATE 剂量为（0.054 mCi/Kg），扫描时间为 2018 年 9 月至 2019 年 5 月。测量肝脏和脾脏的体质量归一化 SUV（SUV）和瘦体重归一化 SUV（SUL）的平均值。收集患者和扫描特征的信息。使用配对 Grambsch 检验比较测量的 SUV 之间的方差。使用 Spearman 秩相关系数评估 SUV 与潜在的患者和扫描特异性混杂因素之间的相关性。
肝脏和脾脏中 SUL 的方差明显低于 SUV 的方差（p 值<0.0001）。肝脏 SUV 和 SUL 的方差明显低于相应的脾脏 SUV。在所有测量的 SUV 中，肝脏 SUL 的方差最低（3.69%±1.25%）。
与 SUV 相比，SUL 是一种更具可重复性、方差更小、因此更可靠的 DOTA PET/CT 扫描定量测量方法。在具有生理摄取的可用器官中，由于肝脏较大且 SUL 值均匀，导致变异性较小，可重复性更好，因此肝脏 SUL 是最佳的内参。
